Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about lysosomal enzyme trafficking: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| IGF2R | mediates | protein | 0.90 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Lysosomal Enzyme Trafficking Correction | 0.489 | neurodegeneration | Autophagy-lysosome pathway convergence a |
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Chaperone-Mediated Autophagy Dysfunction in PD - Experiment Design | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Proteasome-Ubiquitin System Dysfunction Validation in Parkinson's Dise | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $6,550,000 |
| Presymptomatic GRN Carrier Intervention Timing — Biomarker-Guided Ther | clinical | Neurodegeneration | 0.400 | 0.50 | human | proposed | $5,460,000 |
| TMEM106B Haplotype as Genetic Modifier in FTD — Mechanism and Therapeu | validation | Neurodegeneration | 0.400 | 0.50 | human | proposed | $2,730,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Designed endocytosis-inducing proteins degrade targets and amplify signals. [PMID:39322662] | Huang B, Abedi M, Ahn G, Coventry B, Sap | Nature | 2025 | 1 |
| Collapse of late endosomal pH elicits a rapid Rab7 response via the V-ATPase and [PMID:38578235] | Mulligan RJ, Magaj MM, Digilio L, Redema | J Cell Sci | 2024 | 1 |
| IGF2 in memory, neurodevelopmental disorders, and neurodegenerative diseases. [PMID:37031050] | Alberini CM | Trends Neurosci | 2023 | 1 |
| Interactions of IGF-II with the IGF2R/cation-independent mannose-6-phosphate rec [PMID:19251056] | Brown J, Jones EY, Forbes BE | Vitam Horm | 2009 | 1 |
| Soluble ST2 drives fulminant myocarditis progression via the IGF2R-YY1 mitochond [PMID:41684269] | Zhuang Y, Zhang Z, Li H, Abuduwufuer K, | European heart journal | 2026 | 0 |
| Distribution and Levels of Insulin-like Growth Factor 2 Receptor Across Mouse Br [PMID:41725679] | Gaunt JR, Manoj G, Alberini CM | Receptors (Basel, Switzerland) | 2026 | 0 |
| Distinctive respiratory toxicity induced by hypoxanthine metabolic disorder from [PMID:41921402] | Xu X, He M, Lan M, Qiu L, Wang J, Zhong | Environment international | 2026 | 0 |
| Itaconic Acid Activates Lysosomal Biogenesis and Autophagy Flux and Mitigates Hi [PMID:41596065] | Li X, Wang S, Zhang M, Li M, Chen C | Antioxidants (Basel, Switzerla | 2025 | 0 |
| The Pathophysiology of Keratoconus. [PMID:38830186] | ["Vought R", "Greenstein S", "Gelles J", | Cornea | 2025 | 0 |
| The intracellular localization and the ionic permeation of TRPV6 triggers chroni [PMID:41437274] | Fecher-Trost C, Gehl AL, Trunk A, Hellmi | Cell communication and signali | 2025 | 0 |
| CREG1 promotes lysosomal biogenesis and function. [PMID:33966596] | Liu J, Qi Y, Chao J, Sathuvalli P, Y Lee | Autophagy | 2021 | 0 |
| Live imaging of intra-lysosome pH in cell lines and primary neuronal culture usi [PMID:32515674] | Ponsford AH, Ryan TA, Raimondi A, Cocucc | Autophagy | 2021 | 0 |
| Identification and quantitation of the actual active components in bamboo juice [PMID:33184510] | ["Gao Q", "Wang D", "Shao S", "Xue Y", " | Scientific reports | 2020 | 0 |
| TOM1 Regulates Neuronal Accumulation of Amyloid-β Oligomers by FcγRIIb2 Variant [PMID:30185465] | ["Gwon Y", "Kam T", "Kim S", "Song S", " | The Journal of neuroscience : | 2018 | 0 |
| Revisiting LAMP1 as a marker for degradative autophagy-lysosomal organelles in t [PMID:29940787] | Cheng XT, Xie YX, Zhou B, Huang N, Farfe | Autophagy | 2018 | 0 |
| A novel DYRK1A (dual specificity tyrosine phosphorylation-regulated kinase 1A) i [PMID:25556849] | ["Coutadeur S", "Benyamine H", "Delalond | Journal of neurochemistry | 2015 | 0 |
| Hierarchical phosphorylation within the ankyrin repeat domain defines a phosphor [PMID:21685388] | ["Ranganathan P", "Vasquez-Del Carpio R" | The Journal of biological chem | 2011 | 0 |
| A novel rat model with obesity-associated retinal degeneration. [PMID:19369235] | ["Reddy G", "Vasireddy V", "Mandal M", " | Investigative ophthalmology & | 2009 | 0 |
| Protective immune responses against West Nile virus are primed by distinct compl [PMID:16651386] | ["Mehlhop E", "Diamond M"] | The Journal of experimental me | 2006 | 0 |
| Mutations in MRAP, encoding a new interacting partner of the ACTH receptor, caus [PMID:15654338] | ["Metherell L", "Chapple J", "Cooray S", | Nature genetics | 2005 | 0 |