protein

IGF2R

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IGF2R: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

315Connections

1Hypotheses

1Analyses

50Outgoing

50Incoming

Summary

IGF2R is a protein involved in neurodegeneration research. Key relationships include: expressed in, associated with, therapeutic target. Associated with ALS, Aging, Als. Connected to 105 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	IGF2R
Protein Family	Mannose-6-phosphate receptor family
Protein Type	Receptor
Target Class	Receptor
Function	is a protein encoded by the IGF2R gene.
Mechanism of Action	Drugs targeting IGF2R typically work by blocking IGF2 binding and signaling through the IGF1R/IGF2R axis, thereby inhibiting mitogenic and anti-apoptotic effects in cancer cells. Alternatively, agents may enhance IGF2 clearance through IGF2R-mediated endocytosis to reduce circulating IGF2 levels and downstream signaling.
Primary Expression	neurons, astrocytes, and oligodendrocytes, where it participates in the regulation of IGF2 signaling and
Subcellular Localization	Cell membrane, endosomes, lysosomes
Druggability	Low (0.39)
Clinical Stage	Approved
Molecular Weight	274 kDa
Amino Acids	147 aa
Pathways	Lysosomal Enzyme Trafficking, Lysosomal function / degradation, Normal Growth and Development
UniProt ID	A0N9R6
GeneCards	IGF2R
Human Protein Atlas	IGF2R
Associated Diseases	ALS, Aging, Alzheimer, Alzheimer's disease, Amyotrophic Lateral Sclerosis
Known Drugs/Compounds	Linsitinib (OSI-906), Figitumumab (CP-751,871), Ganitumab (AMG 479), MK-0646 (Dalotuzumab)
Interactions	RILP, SORT1, NEK7, Rb, PRDX3, RNF14
SciDEX Target	View Target Profile (2 clinical trials)
SciDEX Hypotheses	Lysosomal Enzyme Trafficking Correction
KG Connections	315 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: IGF2R — AlphaFold A0N9R6 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    IGF2R["IGF2R"]
    IGF2R -->|"expressed in"| neuron["neuron"]
    IGF2R -->|"regulates"| protein_synthesis["protein synthesis"]
    IGF2R -->|"regulates"| protein_trafficking["protein trafficking"]
    IGF2R -->|"regulates"| Als["Als"]
    IGF2R -->|"expressed in"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    IGF2R -->|"expressed in"| Aging["Aging"]
    IGF2R -->|"expressed in"| Alzheimer["Alzheimer"]
    IGF2R -->|"expressed in"| Parkinson["Parkinson"]
    IGF2R -->|"expressed in"| Huntington["Huntington"]
    h_b3d6ecc2["h-b3d6ecc2"] -->|"target for"| IGF2R
    IGF2["IGF2"] -->|"interacts"| IGF2R
    JUN["JUN"] -->|"expressed in"| IGF2R
    RILP["RILP"] -->|"activates"| IGF2R
    YAP["YAP"] -->|"activates"| IGF2R
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"] -->|"target for"| IGF2R
    RAB7A["RAB7A"] -->|"interacts"| IGF2R

Outgoing (208)

Target	Relation	Type	Str
lysosomal enzyme trafficking	mediates	process	0.90
cell growth	regulates	process	0.85
cell survival	regulates	process	0.85
cancer	associated_with	disease	0.85
IGF2 circulating levels	regulates	phenotype	0.85
IGF2 tissue levels	regulates	phenotype	0.85
cell migration	regulates	process	0.80
growth-related disease	implicated_in	disease	0.80
M6PR_protein	encodes	protein	0.80
neuron	expressed_in	cell_type	0.70
protein synthesis	regulates	process	0.70
protein trafficking	regulates	process	0.70
Cancer	associated_with	disease	0.65
Als	regulates	disease	0.65
Als	associated_with	disease	0.65
Amyotrophic Lateral Sclerosis	expressed_in	disease	0.65
Als	expressed_in	disease	0.65
Aging	expressed_in	disease	0.65
Alzheimer	expressed_in	disease	0.65
Parkinson	expressed_in	disease	0.65
Huntington	expressed_in	disease	0.65
Ms	expressed_in	disease	0.65
Als	therapeutic_target	disease	0.65
Aging	associated_with	disease	0.65
Alzheimer	associated_with	disease	0.65
Amyotrophic Lateral Sclerosis	associated_with	disease	0.65
Huntington	associated_with	disease	0.65
Parkinson	associated_with	disease	0.65
Als	activates	disease	0.65
Parkinson	therapeutic_target	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Inflammation	associated_with	disease	0.65
Als	interacts_with	disease	0.65
Ms	interacts_with	disease	0.65
ALS	regulates	disease	0.65
ALS	causes	disease	0.65
ALS	activates	disease	0.65
Infection	associated_with	disease	0.65
Huntington	activates	disease	0.65
Alzheimer	activates	disease	0.65
Aging	activates	disease	0.65
Parkinson	activates	disease	0.65
Amyotrophic Lateral Sclerosis	activates	disease	0.65
Als	causes	disease	0.65
ALS	associated_with	disease	0.65
neurodegeneration	associated_with	disease	0.60
RAB7A	associated_with	gene	0.60
RILP	activates	gene	0.60
RAB7	associated_with	gene	0.60
RILP	associated_with	gene	0.60

Incoming (107)

Source	Relation	Type	Str
h-b3d6ecc2	targets_gene	hypothesis	0.90
Rab7	regulates	protein	0.85
h-b3d6ecc2	targets	hypothesis	0.80
IGF2	interacts_with	protein	0.70
JUN	expressed_in	gene	0.60
IGF2	expressed_in	gene	0.60
RAB7	associated_with	gene	0.60
RILP	activates	gene	0.60
RAB7A	associated_with	gene	0.60
MTOR	associated_with	gene	0.60
RAB7A	interacts_with	gene	0.60
RAB7A	therapeutic_target	gene	0.60
RAB7	causes	gene	0.60
RAB7A	causes	gene	0.60
HSP90AA1	associated_with	gene	0.60
IGF2	regulates	entity	0.60
IGF2	treats	entity	0.60
IDS	associated_with	gene	0.60
SYNCRIP	associated_with	gene	0.60
SSBP1	associated_with	gene	0.60
PRDX3	associated_with	gene	0.60
APP	associated_with	gene	0.60
APOE	associated_with	gene	0.60
SYNE2	associated_with	gene	0.60
SMARCB1	associated_with	gene	0.60
ULK2	associated_with	gene	0.60
TMEM59	associated_with	gene	0.60
SFPQ	associated_with	gene	0.60
CCT4	associated_with	gene	0.60
CALB1	associated_with	gene	0.60
SORL1	associated_with	gene	0.60
RNF14	associated_with	gene	0.60
STXBP3	associated_with	gene	0.60
RILP	causes	gene	0.60
APOE	causes	gene	0.60
APP	causes	gene	0.60
APP	interacts_with	gene	0.60
IDS	interacts_with	gene	0.60
APOE	binds_to	gene	0.60
YAP	activates	gene	0.60
PARKINSON'S DISEASE	therapeutic_target	gene	0.60
NEURODEGENERATIVE DISEASES	associated_with	gene	0.60
NEURODEGENERATIVE DISEASES	interacts_with	gene	0.60
ENDOSOMES	interacts_with	gene	0.60
LYSOSOME	activates	gene	0.60
CANCER	associated_with	gene	0.60
ENDOSOMES	activates	gene	0.60
ALZHEIMER'S DISEASE	expressed_in	gene	0.60
ALZHEIMER	expressed_in	gene	0.60
ALS	expressed_in	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Lysosomal Enzyme Trafficking Correction	0.489	neurodegeneration	Autophagy-lysosome pathway convergence a

Mentioning Analyses (1)

Scientific analyses that reference this entity

Autophagy-lysosome pathway convergence across neurodegenerative diseases

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.665

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Designed endocytosis-inducing proteins degrade targets and amplify signals. [PMID:39322662]	Huang B, Abedi M, Ahn G, Coventry B, Sap	Nature	2025	1
Collapse of late endosomal pH elicits a rapid Rab7 response via the V-ATPase and [PMID:38578235]	Mulligan RJ, Magaj MM, Digilio L, Redema	J Cell Sci	2024	1
IGF2 in memory, neurodevelopmental disorders, and neurodegenerative diseases. [PMID:37031050]	Alberini CM	Trends Neurosci	2023	1
Interactions of IGF-II with the IGF2R/cation-independent mannose-6-phosphate rec [PMID:19251056]	Brown J, Jones EY, Forbes BE	Vitam Horm	2009	1
Soluble ST2 drives fulminant myocarditis progression via the IGF2R-YY1 mitochond [PMID:41684269]	Zhuang Y, Zhang Z, Li H, Abuduwufuer K,	European heart journal	2026	0
Distribution and Levels of Insulin-like Growth Factor 2 Receptor Across Mouse Br [PMID:41725679]	Gaunt JR, Manoj G, Alberini CM	Receptors (Basel, Switzerland)	2026	0
Distinctive respiratory toxicity induced by hypoxanthine metabolic disorder from [PMID:41921402]	Xu X, He M, Lan M, Qiu L, Wang J, Zhong	Environment international	2026	0
Itaconic Acid Activates Lysosomal Biogenesis and Autophagy Flux and Mitigates Hi [PMID:41596065]	Li X, Wang S, Zhang M, Li M, Chen C	Antioxidants (Basel, Switzerla	2025	0
The Pathophysiology of Keratoconus. [PMID:38830186]	["Vought R", "Greenstein S", "Gelles J",	Cornea	2025	0
The intracellular localization and the ionic permeation of TRPV6 triggers chroni [PMID:41437274]	Fecher-Trost C, Gehl AL, Trunk A, Hellmi	Cell communication and signali	2025	0
CREG1 promotes lysosomal biogenesis and function. [PMID:33966596]	Liu J, Qi Y, Chao J, Sathuvalli P, Y Lee	Autophagy	2021	0
Live imaging of intra-lysosome pH in cell lines and primary neuronal culture usi [PMID:32515674]	Ponsford AH, Ryan TA, Raimondi A, Cocucc	Autophagy	2021	0
Identification and quantitation of the actual active components in bamboo juice [PMID:33184510]	["Gao Q", "Wang D", "Shao S", "Xue Y", "	Scientific reports	2020	0
TOM1 Regulates Neuronal Accumulation of Amyloid-β Oligomers by FcγRIIb2 Variant [PMID:30185465]	["Gwon Y", "Kam T", "Kim S", "Song S", "	The Journal of neuroscience :	2018	0
Revisiting LAMP1 as a marker for degradative autophagy-lysosomal organelles in t [PMID:29940787]	Cheng XT, Xie YX, Zhou B, Huang N, Farfe	Autophagy	2018	0
A novel DYRK1A (dual specificity tyrosine phosphorylation-regulated kinase 1A) i [PMID:25556849]	["Coutadeur S", "Benyamine H", "Delalond	Journal of neurochemistry	2015	0
Hierarchical phosphorylation within the ankyrin repeat domain defines a phosphor [PMID:21685388]	["Ranganathan P", "Vasquez-Del Carpio R"	The Journal of biological chem	2011	0
A novel rat model with obesity-associated retinal degeneration. [PMID:19369235]	["Reddy G", "Vasireddy V", "Mandal M", "	Investigative ophthalmology &	2009	0
Protective immune responses against West Nile virus are primed by distinct compl [PMID:16651386]	["Mehlhop E", "Diamond M"]	The Journal of experimental me	2006	0
Mutations in MRAP, encoding a new interacting partner of the ACTH receptor, caus [PMID:15654338]	["Metherell L", "Chapple J", "Cooray S",	Nature genetics	2005	0

IGF2R

Understanding Entity Pages

Summary

Wiki Pages (21)

IGF2R Protein

Autophagy Mechanisms

autophagy-lysosomal-alzheimers

Autophagy-Lysosomal Pathway in Parkinson's Disease

autophagy-lysosome-dysfunction

Autophagy Types in Neurodegeneration

autophagy-lysosomal-ad

autophagy

Autophagy-Impaired Neurons

IGF2 Protein (Insulin-like Growth Factor 2)

Autophagy-Lysosome Pathway in Neurodegeneration

Targeted Protein Degradation (PROTACs)

Section 253: Respiratory Function and Dysphagia Therapy in CBS/PSP

Autophagy-Enhancing Therapies

Autophagy-Lysosomal Dysfunction in Neurodegenerative Diseases

Autophagy-Lysosomal Dysfunction Neurons

Autophagy and Mitophagy Therapeutics Investment Landscape

SYNE2 Gene

Autophagy Molecular Regulation in Neurodegeneration

Section 117: Long-Term Disease Modification Endpoints for CBS/PSP