Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about lysosomal swelling: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| RAB10 hyperphosphorylation | amplifies | mechanism | 0.70 |
| LRRK2 recruitment | triggers | mechanism | 0.70 |
| LRRK2 activation | triggers | mechanism | 0.70 |
| LRRK2 activation | induces | process | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| G2019S primarily raises baseline LRRK2 kinase activity rathe | 0.790 | neurodegeneration | Do pathogenic LRRK2 mutations amplify vo |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-24 | 5 hypotheses Top: 0.790
neurodegeneration | 2026-04-23 | 7 hypotheses Top: 0.780
neurodegeneration | 2026-04-16 | 1 hypotheses Top: 0.666
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| LRRK2 kinase-mediated accumulation of lysosome-associated phospho-Rabs in tauopa [PMID:41128923] | Buck SA, Malankhanova T, Strader S, Ma E | Acta neuropathologica | 2025 | 0 |
| RAB12-LRRK2 complex suppresses primary ciliogenesis and regulates centrosome hom [PMID:39343966] | Li X, Zhu H, Huang BT, Li X, Kim H, Tan | Nature communications | 2024 | 0 |
| Exploring the focal role of LRRK2 kinase in Parkinson's disease. [PMID:35147886] | ["Kumar Sachin", "Behl Tapan", "Sehgal A | Environmental science and poll | 2022 | 0 |
| Elevated Urinary Rab10 Phosphorylation in Idiopathic Parkinson Disease. [PMID:35521944] | Wang S, Unnithan S, Bryant N | Mov Disord | 2022 | 0 |
| Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disea [PMID:33182554] | Marogianni C, Sokratous M, Dardiotis E, | International journal of molec | 2020 | 0 |
| Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disea [PMID:33182554] | Marogianni C, Sokratous M, Dardiotis E, | International journal of molec | 2020 | 0 |
| Rab GTPases as Physiological Substrates of LRRK2 Kinase. [PMID:31138985] | Seol W, Nam D, Son I | Exp Neurobiol | 2019 | 0 |
| Multiple Sclerosis Pathology. [PMID:29358320] | Lassmann H | Cold Spring Harbor perspective | 2018 | 0 |
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.80 · 2026-04-26
closed · Rounds: 4 · Score: 0.74 · 2026-04-24
closed · Rounds: 4 · Score: 0.85 · 2026-04-16
Hypotheses and analyses mentioning lysosomal swelling in their description or question text
No additional research found