Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about TREHALOSE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
TREHALOSE is a concept in neurodegeneration research. Key relationships include: activates, expressed in. Associated with Als, Amyotrophic Lateral Sclerosis, Ataxia. Connected to 98 entities in the SciDEX knowledge graph.
| Name | TREHALOSE |
| Key Genes/Proteins | TFEB, AUTOPHAGY, GDNF, FOXO3, TAU |
| Related Diseases | Atherosclerosis, Huntington, Spinocerebellar Ataxia, Amyotrophic Lateral Sclerosis, Parkinson |
| Related Pathways | Autophagy, Mtor |
Knowledge base pages for this entity
graph TD
TREHALOSE["TREHALOSE"]
TREHALOSE -->|"activates"| TFEB["TFEB"]
TREHALOSE -->|"activates"| autophagy["autophagy"]
TREHALOSE -->|"treats"| multiple_sclerosis["multiple sclerosis"]
TREHALOSE -->|"activates"| remyelination["remyelination"]
TREHALOSE -->|"activates"| Atherosclerosis["Atherosclerosis"]
TREHALOSE -->|"activates"| Huntington["Huntington"]
TREHALOSE -->|"activates"| Spinocerebellar_Ataxia["Spinocerebellar Ataxia"]
TREHALOSE -->|"activates"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
TREHALOSE -->|"activates"| Parkinson["Parkinson"]
P62["P62"] -->|"activates"| TREHALOSE
SOD1["SOD1"] -->|"activates"| TREHALOSE
MAP1LC3B["MAP1LC3B"] -->|"activates"| TREHALOSE
LGALS3["LGALS3"] -->|"activates"| TREHALOSE
MCOLN1["MCOLN1"] -->|"activates"| TREHALOSE
STIP1["STIP1"] -->|"activates"| TREHALOSE
AUTOPHAGY["AUTOPHAGY"] -->|"activates"| TREHALOSE
ALS["ALS"] -->|"activates"| TREHALOSE
SQSTM1["SQSTM1"] -->|"activates"| TREHALOSE
PPARGC1A["PPARGC1A"] -->|"activates"| TREHALOSE| Target | Relation | Type | Str |
|---|---|---|---|
| TFEB | activates | gene | 0.95 |
| NEURODEGENERATION | protects_against | entity | 0.85 |
| LYSOSOME | modulates | entity | 0.85 |
| AUTOPHAGY | activates | gene | 0.70 |
| Autophagy | activates | pathway | 0.70 |
| Mtor | activates | pathway | 0.70 |
| GDNF | protects_against | gene | 0.70 |
| GDNF | destabilizes | gene | 0.70 |
| FOXO3 | activates | gene | 0.70 |
| TAU | activates | protein | 0.70 |
| Atherosclerosis | activates | disease | 0.65 |
| Huntington | activates | disease | 0.65 |
| Spinocerebellar Ataxia | activates | disease | 0.65 |
| Amyotrophic Lateral Sclerosis | activates | disease | 0.65 |
| Parkinson | activates | disease | 0.65 |
| Ataxia | activates | disease | 0.65 |
| Neurodegeneration | activates | disease | 0.65 |
| Neuroblastoma | activates | disease | 0.65 |
| Als | activates | disease | 0.65 |
| OXIDATIVE STRESS | inhibits | phenotype | 0.65 |
| PARP1 | inhibits | gene | 0.65 |
| PARP1 | activates | gene | 0.65 |
| JNK | inhibits | gene | 0.65 |
| JNK | activates | gene | 0.65 |
| ERK | regulates | gene | 0.65 |
| OXIDATIVE STRESS | activates | phenotype | 0.65 |
| TFEB | treats | gene | 0.65 |
| MITOCHONDRIAL DYSFUNCTION | inhibits | phenotype | 0.65 |
| MTOR | inhibits | gene | 0.65 |
| LYSOSOMAL BIOGENESIS | activates | gene | 0.60 |
| NEURODEGENERATIVE DISORDERS | activates | gene | 0.60 |
| MTORC1 | activates | gene | 0.60 |
| MTOR | activates | gene | 0.60 |
| P62 | activates | gene | 0.60 |
| DNA | activates | gene | 0.60 |
| TPP1 | activates | gene | 0.60 |
| PPP3 | activates | gene | 0.60 |
| SOD1 | activates | gene | 0.60 |
| TREH | activates | gene | 0.60 |
| PARKINSON | activates | gene | 0.60 |
| STUB1 | activates | gene | 0.60 |
| ATG | activates | gene | 0.60 |
| STIP1 | activates | gene | 0.60 |
| SQSTM1 | activates | gene | 0.60 |
| NEURODEGENERATIVE DISEASES | activates | gene | 0.60 |
| GAPDH | activates | gene | 0.60 |
| ALS | activates | gene | 0.60 |
| CTSB | activates | gene | 0.60 |
| PPP3CB | activates | gene | 0.60 |
| NEURODEGENERATION | activates | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| NEURON | activates | cell_type | 0.65 |
| TFEB | promotes | gene | 0.65 |
| NEURON | causes | cell_type | 0.65 |
| TFEB | degrades | gene | 0.65 |
| TFEB | inhibits | gene | 0.65 |
| P62 | activates | gene | 0.60 |
| SOD1 | activates | gene | 0.60 |
| MAP1LC3B | activates | gene | 0.60 |
| LGALS3 | activates | gene | 0.60 |
| MCOLN1 | activates | gene | 0.60 |
| STIP1 | activates | gene | 0.60 |
| AUTOPHAGY | activates | gene | 0.60 |
| ALS | activates | gene | 0.60 |
| SQSTM1 | activates | gene | 0.60 |
| PPARGC1A | activates | gene | 0.60 |
| HUNTINGTON | activates | gene | 0.60 |
| PARKINSON | activates | gene | 0.60 |
| STUB1 | activates | gene | 0.60 |
| ATG | activates | gene | 0.60 |
| HSPB8 | activates | gene | 0.60 |
| TREH | activates | gene | 0.60 |
| NEURODEGENERATION | activates | gene | 0.60 |
| ATG12 | activates | gene | 0.60 |
| TARDBP | activates | gene | 0.60 |
| PPP3CB | activates | gene | 0.60 |
| CTSB | activates | gene | 0.60 |
| DNA | activates | gene | 0.60 |
| GENES | activates | gene | 0.60 |
| LAMP1 | activates | gene | 0.60 |
| GAPDH | activates | gene | 0.60 |
| HSPA8 | activates | gene | 0.60 |
| ATG10 | activates | gene | 0.60 |
| GLA | activates | gene | 0.60 |
| MTOR | activates | gene | 0.60 |
| AMYOTROPHIC LATERAL SCLEROSIS | activates | gene | 0.60 |
| CALCINEURIN | activates | gene | 0.60 |
| BECN1 | activates | gene | 0.60 |
| TFEB | activates | gene | 0.60 |
| LAMP2A | activates | gene | 0.60 |
| TPP1 | activates | gene | 0.60 |
| PPP3 | activates | gene | 0.60 |
| NEURODEGENERATIVE DISEASES | activates | gene | 0.60 |
| BCL2 | activates | gene | 0.60 |
| BAG3 | activates | gene | 0.60 |
| AND | activates | gene | 0.60 |
| MTORC1 | activates | gene | 0.60 |
| NEURODEGENERATIVE DISORDERS | activates | gene | 0.60 |
| RNA | activates | gene | 0.60 |
| Autophagy | activates | process | 0.50 |
| disease | activates | disease | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
neurodegeneration | 2026-04-08 | 0 hypotheses
neurodegeneration | 2026-04-07 | 0 hypotheses
neurodegeneration | 2026-04-07 | 0 hypotheses
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||