concept

TREHALOSE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TREHALOSE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

226Connections
0Hypotheses
3Analyses
50Outgoing
50Incoming

Summary

TREHALOSE is a concept in neurodegeneration research. Key relationships include: activates, expressed in. Associated with Als, Amyotrophic Lateral Sclerosis, Ataxia. Connected to 98 entities in the SciDEX knowledge graph.

View on Wiki →

💡 Concept Info
NameTREHALOSE
Key Genes/ProteinsTFEB, AUTOPHAGY, GDNF, FOXO3, TAU
Related DiseasesAtherosclerosis, Huntington, Spinocerebellar Ataxia, Amyotrophic Lateral Sclerosis, Parkinson
Related PathwaysAutophagy, Mtor

Wiki Pages (20)

Knowledge base pages for this entity

cbs-psp-daily-action-plan

therapeutic · 30834 words

Progressive Supranuclear Palsy (PSP)

disease · 12907 words

PD Combination Therapy Matrix

mechanism · 5949 words

Therapeutics

index · 5665 words

CBS/PSP Treatment Rankings

therapeutic · 5434 words

Pathway Diagram

graph TD
    TREHALOSE["TREHALOSE"]
    TREHALOSE -->|"activates"| TFEB["TFEB"]
    TREHALOSE -->|"activates"| autophagy["autophagy"]
    TREHALOSE -->|"treats"| multiple_sclerosis["multiple sclerosis"]
    TREHALOSE -->|"activates"| remyelination["remyelination"]
    TREHALOSE -->|"activates"| Atherosclerosis["Atherosclerosis"]
    TREHALOSE -->|"activates"| Huntington["Huntington"]
    TREHALOSE -->|"activates"| Spinocerebellar_Ataxia["Spinocerebellar Ataxia"]
    TREHALOSE -->|"activates"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    TREHALOSE -->|"activates"| Parkinson["Parkinson"]
    P62["P62"] -->|"activates"| TREHALOSE
    SOD1["SOD1"] -->|"activates"| TREHALOSE
    MAP1LC3B["MAP1LC3B"] -->|"activates"| TREHALOSE
    LGALS3["LGALS3"] -->|"activates"| TREHALOSE
    MCOLN1["MCOLN1"] -->|"activates"| TREHALOSE
    STIP1["STIP1"] -->|"activates"| TREHALOSE
    AUTOPHAGY["AUTOPHAGY"] -->|"activates"| TREHALOSE
    ALS["ALS"] -->|"activates"| TREHALOSE
    SQSTM1["SQSTM1"] -->|"activates"| TREHALOSE
    PPARGC1A["PPARGC1A"] -->|"activates"| TREHALOSE

Outgoing (159)

TargetRelationTypeStr
TFEBactivatesgene0.95
NEURODEGENERATIONprotects_againstentity0.85
LYSOSOMEmodulatesentity0.85
AUTOPHAGYactivatesgene0.70
Autophagyactivatespathway0.70

Incoming (67)

SourceRelationTypeStr
NEURONactivatescell_type0.65
TFEBpromotesgene0.65
NEURONcausescell_type0.65
TFEBdegradesgene0.65
TFEBinhibitsgene0.65

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (3)

Scientific analyses that reference this entity

Why do structurally diverse sugars (trehalose, melibiose, lactulose) produce ide

neurodegeneration | 2026-04-08 | 0 hypotheses

What determines the specificity of calcium-dependent PPP3/calcineurin activation

neurodegeneration | 2026-04-07 | 0 hypotheses

How does controlled lysosomal membrane permeabilization induce autophagy without

neurodegeneration | 2026-04-07 | 0 hypotheses

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found