mechanism 1,218 words KG: ent-gene-9f063e98
Contents

LRRK2 in Corticobasal Syndrome and 4R-Tauopathies

🔬 Protein Info
Gene Symbolent-gene-9f063e98
Kinase domainPhosphorylates multiple substrates
ANK repeat domainProtein-protein interactions
LRR domainLeucine-rich repeat, potentially involved in substrate recognition
Rab proteinsRab10, Rab8, Rab35 (involved in membrane trafficking)
Tau proteinDirect phosphorylation at disease-relevant sites
SynapsinSynaptic vesicle regulation
MAP1BMicrotubule-associated protein
KG Connections22 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Related Hypotheses (13)

Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.38
Purinergic Signaling Polarization Control
Score: 0.71
Mechanosensitive Ion Channel Reprogramming
Score: 0.70
Lipid Droplet Dynamics as Phenotype Switches
Score: 0.67
TREM2-mediated microglial tau clearance enhancement
Score: 0.62
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69
APOE-Dependent Autophagy Restoration
Score: 0.89
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76
APOE-TREM2 Interaction Modulation
Score: 0.74
The Mitochondrial-Lysosomal Metabolic Coupling Dysfunction
Score: 0.65
TFEB-PGC1α Mitochondrial-Lysosomal Decoupling
Score: 0.62
TREM2-Dependent Microglial Senescence Transition
Score: 0.62
TREM2-Mediated Selective Aggregate Clearance Pathway
Score: 0.58

Related Analyses (27)

Synaptic pruning by microglia in early AD
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completed
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived

Related Experiments (26)

LRRK2/GBA Mutation Carrier Resilience — Why Some Carriers Ne
validation · completed · Score: 0.40
AAV-LRRK2 IND-Enabling Study Design
clinical · proposed · Score: 0.40
AAV Serotype Comparison for LRRK2 Knockdown in PD
validation · proposed · Score: 0.40
Alpha-Synuclein Aggregation Triggers — Sporadic PD Initiatio
clinical · proposed · Score: 0.40
Computational Modeling of Alpha-Synuclein Propagation in PD
validation · proposed · Score: 0.40

See Also (15)

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HMGB1 Signaling in Neurodegeneration
mechanism · Pages share 5 hypotheses
Rotigotine and Rivastigmine Combination Therapy for Alz
clinical · Pages share 5 hypotheses
Convergent Pathways in Neurodegeneration
mechanism · Pages share 5 hypotheses
Endosomal-Lysosomal Pathway in Neurodegeneration
mechanism · Pages share 5 hypotheses

Knowledge Graph (12 edges)

40690364 counteracts ent-gene-9f063e98
40690364 phosphorylates ent-gene-9f063e98
38307024 phosphorylates and inactivates ent-gene-9f063e98
33177079 is recruited to ent-gene-9f063e98
33177079 recruits ent-gene-9f063e98
33177079 recruits JIP4 to lysosomes via phosphorylation of ent-gene-9f063e98
33177079 is orchestrated by ent-gene-9f063e98
32853409 phosphorylates ent-gene-9f063e98
34125248 is an endogenous substrate of ent-gene-9f063e98
38307024 phosphorylates ent-gene-9f063e98

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