| Gene Symbol | LRRK2 |
| Full Name | GBA Combination Therapy for Parkinson's Disease |
| Chromosome | 12q12 |
| Protein Type | Protein |
| Amino Acids | 2527 aa |
| Pathways | MAPK |
| UniProt ID | Search UniProt |
| GeneCards | LRRK2 |
| Human Protein Atlas | LRRK2 |
| Observation | Finding |
| Population frequency | ~5% LRRK2-G2019S carriers also carry GBA variants[@[m2020]] |
| Phenotype | Combined carriers show earlier onset, faster progression[@[m2020]] |
| Mechanistic synergy | Both pathways converge on lysosomal function[@[m2020]] |
| Therapeutic rationale | Combination may provide enhanced benefit |
| Armadillo repeats | Protein-protein interactions |
| Associated Diseases | ALS, Aging, Alzheimer, Alzheimer's disease, Amyotrophic Lateral Sclerosis |
| Known Drugs/Compounds | RAPAMYCIN, levodopa, Cigarette Smoking, MLi-2, PF-06447475, Environmental Toxicants |
| Interactions | ATG16L1, RB1CC1, GABARAP, ERN1, STAT3, IFNG |
| KG Connections | 2480 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |