Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about sumoylation: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Protein Sumoylation In Neurodegeneration is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| Name | sumoylation |
Knowledge base pages for this entity
flowchart TD
SUMOylation["SUMOylation"] -->|"modulates"| Proteostatic_Integrity["Proteostatic Integrity"]
SUMOylation["SUMOylation"] -->|"modulates"| Proteostasis["Proteostasis"]
Sumoylation["Sumoylation"] -->|"regulates"| Circadian_Clock_Gene_Regulatio["Circadian Clock Gene Regulation"]
ANXA1["ANXA1"] -->|"involved in"| Sumoylation["Sumoylation"]
__SYNUCLEIN["Alpha-SYNUCLEIN"] -->|"involved in"| Sumoylation["Sumoylation"]
Tardbp["Tardbp"] -->|"associated with"| SUMOylation["SUMOylation"]
ANXA1["ANXA1"] -->|"undergoes"| SUMOYLATION["SUMOYLATION"]
style SUMOylation fill:#5d4400,stroke:#333,color:#e0e0e0
style Proteostatic_Integrity fill:#5d4400,stroke:#333,color:#e0e0e0
style Proteostasis fill:#5d4400,stroke:#333,color:#e0e0e0
style Sumoylation fill:#5d4400,stroke:#333,color:#e0e0e0
style Circadian_Clock_Gene_Regulatio fill:#5d4400,stroke:#333,color:#e0e0e0
style ANXA1 fill:#4a1a6b,stroke:#333,color:#e0e0e0
style __SYNUCLEIN fill:#006494,stroke:#333,color:#e0e0e0
style Tardbp fill:#006494,stroke:#333,color:#e0e0e0
style SUMOYLATION fill:#5d4400,stroke:#333,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Proteostatic Integrity | modulates | process | 0.72 |
| Circadian Clock Gene Regulation | regulates | process | 0.70 |
| Proteostasis | modulates | process | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| ANXA1 | involved_in | protein | 0.90 |
| ANXA1 | involved_in | protein | 0.85 |
| Tardbp | associated_with | protein | 0.85 |
| Α-SYNUCLEIN | involved_in | protein | 0.85 |
| ANXA1 | undergoes | gene | 0.80 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||