protein

ANXA1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ANXA1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

529Connections

1Hypotheses

1Analyses

50Outgoing

50Incoming

1Experiments

1Debates

Summary

ANXA1 is a protein involved in neurodegeneration research. Key relationships include: regulates, contributes to, activates. Associated with ALS, Acute Ischemic Stroke, Aging. Connected to 189 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	ANXA1
Full Name	Annexin A1
Chromosome	9q21.13
Target Class	Signaling Protein
Function	ANXA1 performs diverse cellular functions:
Mechanism of Action	Calcium-dependent phospholipid binding protein modulator
Primary Expression	the nervous system:
Druggability	Low (0.41)
Clinical Stage	Approved
Molecular Weight	~37 kDa
Amino Acids	346 aa
Exons	13
Pathways	Apoptosis, Blood-Brain Barrier, Immune Response, Mtor, cGAS/STING Pathway
UniProt ID	P04083
NCBI Gene ID	303
Ensembl ID	ENSG00000109255
OMIM	151690
GeneCards	ANXA1
Human Protein Atlas	ANXA1
Associated Diseases	aging, ALS, Alzheimer, cancer
Known Drugs/Compounds	aducanumab, GW201, Tat-Nts, Tat-NTS, Tat-NTS peptide
Interactions	AKT, AMPK, AND, APOPTOSIS, AUTOPHAGY, BECN1
SciDEX Target	View Target Profile (8 clinical trials)
SciDEX Hypotheses	Synaptic Phosphatidylserine Masking via Annexin A1
KG Connections	528 knowledge graph edges
Databases	GeneCards HPA STRING

🧬 3D Structure Comparison — ANXA1 Experimental (PDB) vs Predicted (AlphaFold) — click to expand

📄 Experimental Structure

1HM6 — X-ray / Cryo-EM

🔮 AI Predicted Structure

P04083 — AlphaFold

Left: Experimental structure from RCSB PDB | Right: AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (4)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    ANXA1["ANXA1"] -->|"associated"| Efferocytosis["Efferocytosis"]
    ANXA1["ANXA1"] -->|"expressed in"| CD68__Macrophages["CD68+ Macrophages"]
    ANXA1["ANXA1"] -->|"regulates"| cGAS_STING_Pathway["cGAS/STING Pathway"]
    ANXA1["ANXA1"] -->|"biomarker for"| Pancreatic_Cancer["Pancreatic Cancer"]
    ANXA1["ANXA1"] -->|"associated"| Antitumor_Immune_Responses["Antitumor Immune Responses"]
    ANXA1["ANXA1"] -->|"biomarker for"| bladder_cancer["bladder cancer"]
    h_513a633f["h-513a633f"] -->|"targets"| ANXA1["ANXA1"]
    CASP3["CASP3"] -->|"associated"| ANXA1["ANXA1"]
    JUN["JUN"] -->|"therapeutic target"| ANXA1["ANXA1"]
    TNF["TNF"] -->|"therapeutic target"| ANXA1["ANXA1"]
    style ANXA1 fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (444)

Target	Relation	Type	Str
Leukocyte-Mediated Immune Response	regulates	process	0.95
Efferocytosis	associated_with	process	0.95
Macrophage Efferocytosis	regulates	process	0.95
Macrophages	expressed_in	cell_type	0.95
MICROGLIA	modulates	cell_type	0.95
Leukocyte-Mediated Immune Response	inhibits	process	0.95
Cgas/Sting Pathway	inhibits	pathway	0.95
Inflammation	inhibits	process	0.95
Efferocytosis	promotes	process	0.95
Cd68+ Macrophages	expressed_in	cell_type	0.95
Microglia/Macrophage Polarization	modulates	process	0.95
Cerebral Ischemia-Reperfusion Injury	protects_against	disease	0.95
myocardial membrane repair	mediates	process	0.95
donation after circulatory death complications	therapeutic_target	disease	0.92
CD68+ Macrophages	expressed_in	cell_type	0.92
INFLAMMATION	inhibits	process	0.92
Tumor Growth	promotes	phenotype	0.92
Pro-Inflammatory Macrophages	upregulates	cell_type	0.90
Microglia Polarization	modulates	process	0.90
leukocyte-mediated immune responses	inhibits	process	0.90
Effector T Cells	upregulates	cell_type	0.90
Macrophage Polarization	modulates	process	0.90
warm ischemic injury	protects_against	phenotype	0.90
Sumoylation	involved_in	process	0.90
PI3K/AKT pathway	activates	pathway	0.90
Apoptotic Cell Accumulation	inhibits	phenotype	0.90
cGAS/STING Pathway	regulates	pathway	0.90
macrophage	modulates	cell_type	0.90
inflammation	suppresses	process	0.90
Pancreatic Cancer	associated_with	disease	0.90
Apoptosis	inhibits	process	0.90
Anti-Inflammatory Response	promotes	process	0.88
Survival	biomarker_for	phenotype	0.88
Plasma Membrane Repair	mediates	process	0.88
Ischemic Injury	biomarker_for	phenotype	0.85
Central Inflammation	modulates	process	0.85
Blood-Brain Barrier Integrity	modulates	process	0.85
FPR2	binds	receptor	0.85
Homeostasis	associated_with	process	0.85
Hormonal Secretion	modulates	process	0.85
Pancreatic Cancer	biomarker_for	disease	0.85
Blood-Brain Barrier Integrity	involved_in	process	0.85
Endocrine Control	modulates	process	0.85
Hormonal Secretion	regulates	process	0.85
Immune Repair	involved_in	process	0.85
Efferocytosis	regulates	process	0.85
Cellular Signalling	modulates	process	0.85
Peripheral Inflammation	modulates	process	0.85
Microglial Activation	regulates	process	0.85
Nuclear Localization	involved_in	process	0.85

Incoming (85)

Source	Relation	Type	Str
MIR374B	downregulates	gene	0.95
Tat-Nts	targets	drug	0.95
Cd68+ Macrophages	expressed_in	cell_type	0.92
Tat-NTS	targets	drug	0.90
Tat-NTS peptide	binds	drug	0.90
h-513a633f	targets_gene	hypothesis	0.90
warm ischemic time	downregulates	process	0.90
LINC00491	upregulates	gene	0.90
PURA	inhibits	protein	0.85
GW201	modulates	compound	0.85
ALX	binds	receptor	0.85
FPR2	binds	receptor	0.85
Purα	inhibits	protein	0.85
cGAS/STING Pathway	activates	pathway	0.80
h-513a633f	targets	hypothesis	0.80
MICROGLIA	SUMOylates	cell_type	0.80
TAT-NTS	promotes_SUMOylation_of	compound	0.80
GW201	upregulates	compound	0.75
AND	activates	gene	0.60
BECN1	modulates	gene	0.60
CANCER	implicated_in	gene	0.60
ALZHEIMER'S DISEASE	implicated_in	gene	0.60
DEPRESSION	implicated_in	gene	0.60
AND	contributes_to	gene	0.60
ALZHEIMER	implicated_in	gene	0.60
CGAS-STING	inhibits	gene	0.60
CANCER	activates	gene	0.60
AGING	transports	gene	0.60
TNF	therapeutic_target	gene	0.60
NBR1	activates	gene	0.60
CX3CR1	therapeutic_target	gene	0.60
NTS	protects_against	gene	0.60
MTOR	regulates	gene	0.60
CD68	expressed_in	gene	0.60
CGAS	inhibits	gene	0.60
STING	activates	gene	0.60
ANXA2	contributes_to	gene	0.60
OVERVIEW	regulates	gene	0.60
CANCER	regulates	gene	0.60
CASP3	associated_with	gene	0.60
JUN	therapeutic_target	gene	0.60
IL-1	therapeutic_target	gene	0.60
DEPRESSION	therapeutic_target	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
CANCER	contributes_to	gene	0.60
CX3CR1	activates	gene	0.60
JUN	contributes_to	gene	0.60
AKT	activates	gene	0.60
AKT	expressed_in	gene	0.60
AKT	regulates	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Synaptic Phosphatidylserine Masking via Annexin A1 Mimetics	0.680	neurodegeneration	Synaptic pruning by microglia in early A

Mentioning Analyses (1)

Scientific analyses that reference this entity

Synaptic pruning by microglia in early AD

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.739

Experiments (1)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Basic Mechanism: Membrane-Driven Alpha-Synuclein Nucleation	validation	Parkinson's Disease	0.400	0.50	human	proposed	$2,730,000

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Loss of Annexin A1 in macrophages restrains efferocytosis and remodels immune mi [PMID:39237260]	Hou Z, Lu F, Lin J, Wu Y, Chen L, Fang H	J Immunother Cancer	2024	1
The role of annexins in central nervous system development and disease. [PMID:38639785]	White ZB 2nd, Nair S, Bredel M	J Mol Med (Berl)	2024	1
Tat-NTS peptide protects neurons against cerebral ischemia-reperfusion injury vi [PMID:37908731]	Zhou H, Yan L, Huang H, Li X, Xia Q, Zhe	Theranostics	2023	1
Annexin A1 protects against cerebral ischemia-reperfusion injury by modulating m [PMID:34022892]	Xu X, Gao W, Li L, Hao J, Yang B, Wang T	J Neuroinflammation	2021	1
Annexin A1: Uncovering the Many Talents of an Old Protein. [PMID:29614751]	Sheikh MH, Solito E	Int J Mol Sci	2018	1
LINC00491 promotes nasopharyngeal carcinoma metastasis by binding to purine-rich [PMID:41903631]	["Liu Y", "Li H", "Zhang J", "Peng J", "	International journal of biolo	2026	0
GW201 mediates neuroprotection via allosteric modulation of NMDA receptor activi [PMID:41693050]	["Tiliwaerde M", "Zhaoji D", "Jingjing L	British journal of pharmacolog	2026	0
Annexin A1 enhances liver repair after acetaminophen-induced liver injury by reg [PMID:41707743]	["Zha L", "Liu D", "Zhan M", "Xu Y", "Ha	Free radical biology & medicin	2026	0
Myeloid cell-specific β2-adrenergic receptor deletion improves early cardiac inj [PMID:41695468]	["Nayak T", "Bajpai A", "Patwa V", "Cart	Theranostics	2026	0
Sex-specific hypothalamic PVN transcriptomic signatures of blood pressure autono [PMID:41723507]	["Duque V", "Nani J", "Jovanovic M", "Lo	Biology of sex differences	2026	0
Attenuated crosstalk between urothelium and fibroblasts promotes ureteral strict [PMID:41924262]	["Guo R", "Zhang X", "Wang C", "Cui J",	Frontiers in immunology	2026	0
AnnexinA1-Dectin 1 axis is a key regulator of osteoclastogenesis underlying irra [PMID:41925240]	["Guliyeva G", "Takile F", "Stallfort V"	Journal of bone and mineral re	2026	0
Characterization of ANXA1 in chemotherapy resistance of head and neck squamous c [PMID:41836290]	["Zheng L", "Yang H", "Cheng Y", "Xia B"	Frontiers in cell and developm	2026	0
The invasion phenotypes of glioblastoma depend on plastic and reprogrammable cel [PMID:40683881]	["Doroszko M", "Stockgard R", "Uppman I"	Nature communications	2025	0
Loss of Endothelial Annexin A1 Aggravates Inflammation-Induched Vascular Aging. [PMID:38358087]	You Q, Ke Y, Chen X, Yan W, Li D, Chen L	Advanced science (Weinheim, Ba	2024	0
Anxa1 in smooth muscle cells protects against acute aortic dissection. [PMID:33757117]	Zhou C, Lin Z, Cao H, Chen Y, Li J, Zhua	Cardiovascular research	2022	0
Immunogenic Cell Death by the Novel Topoisomerase I Inhibitor TLC388 Enhances th [PMID:33799527]	["Huang K", "Chiang S", "Yang P", "Ke T"	Cancers	2021	0
Identification of AnnexinA1 as an Endogenous Regulator of RhoA, and Its Role in [PMID:30972066]	["Purvis G", "Collino M", "Loiola R", "B	Frontiers in immunology	2019	0
Annexin A1-derived peptide Ac [PMID:30755225]	["Gimenes A", "Andrade B", "Pinotti J",	Journal of neuroinflammation	2019	0
Annexins-Coordinators of Cholesterol Homeostasis in Endocytic Pathways. [PMID:29757220]	Rentero C, Blanco-Muñoz P, Meneses-Salas	International journal of molec	2018	0

Debates (1)

Multi-agent debates referencing this entity

Synaptic pruning by microglia in early AD

closed · Rounds: 4 · Score: 0.95 · 2026-04-06

ANXA1

Understanding Entity Pages

Summary

Wiki Pages (4)

ANXA1 — Annexin A1

ANXA11 — Annexin A11

ANXA1 Protein — Annexin A1

ANXA11 Protein — Annexin A11

Pathway Diagram

Outgoing (444)

Incoming (85)

Targeting Hypotheses (1)

Mentioning Analyses (1)

Synaptic pruning by microglia in early AD

Experiments (1)

Related Papers (20)

Debates (1)

Synaptic pruning by microglia in early AD