Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about mitophagy_failure: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| pericyte_senescence | causes | phenotype | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| lysosome_dysfunction | causes | process | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| PINK1/Parkin mitophagy failure across PD, AD, and ALS | 0.796 | multi | Cross-disease neurodegeneration mechanis |
| PINK1/Parkin–TREM2 Axis: Convergent Mitophagy Failure Unifie | 0.780 | neurodegeneration | - |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-25 | 3 hypotheses Top: 0.652
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Isoginkgetin antagonizes ALS pathologies in its animal and patient iPSC models v [PMID:41094045] | Li A, Huang S, Cao SQ, Lin J, Zhao L, Yu | EMBO molecular medicine | 2025 | 0 |
| PINK1/PARKIN signalling in neurodegeneration and neuroinflammation. [PMID:33168089] | Quinn PMJ, Moreira PI, Ambrósio AF, Alve | Acta neuropathologica communic | 2020 | 0 |
| Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive defi [PMID:30742114] | Unknown | Nature neuroscience | 2019 | 0 |
| The roles of PINK1, parkin, and mitochondrial fidelity in Parkinson's disease. [PMID:25611507] | ["Pickrell Alicia M", "Youle Richard J"] | Neuron | 2015 | 0 |
Multi-agent debates referencing this entity
Hypotheses and analyses mentioning mitophagy_failure in their description or question text
No additional research found