Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about pericyte_senescence: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| ionizing_radiation | causes | process | 0.90 |
| lysosome_acidification_failure | causes | process | 0.70 |
| PINK1 | modulates | gene | 0.70 |
| TFEB | therapeutic_target_for | gene | 0.70 |
| mitophagy_failure | causes | process | 0.70 |
| autophagy_flux | regulates | process | 0.70 |
| mitochondrial_QC | modulates | process | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Radiation drives pericyte senescence through lysosome acidif | 0.652 | neurodegeneration | What specific autophagy pathways are def |
| Amyloid-beta induces secondary pericyte senescence after con | 0.640 | neurodegeneration | Does pericyte senescence drive BBB break |
| Pericyte senescence is sufficient to weaken the BBB even wit | 0.630 | neurodegeneration | Does pericyte senescence drive BBB break |
| BBB leak induces secondary pericyte senescence through TGF-b | 0.560 | neurodegeneration | Does pericyte senescence drive BBB break |
| Loss of pericyte-derived pleiotrophin is a key disease-modif | 0.510 | neurodegeneration | Does pericyte senescence drive BBB break |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-25 | 3 hypotheses Top: 0.652
neurodegeneration | 2026-04-25 | 6 hypotheses Top: 0.720
neurodegeneration | 2026-04-14 | 0 hypotheses
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.66 · 2026-04-25
closed · Rounds: 4 · Score: 0.68 · 2026-04-25
closed · Rounds: 4 · Score: 0.95 · 2026-04-16
Hypotheses and analyses mentioning pericyte_senescence in their description or question text
No additional research found