Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about myelin_breakdown: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| early_AD | associated_with | disease | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| oligodendrocytes | vulnerable_to | cell_type | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Myelin Breakdown-Amyloid Interaction Amplifies Cortical Agin | 0.512 | alzheimer | Allen Mouse Brain Aging Atlas: cross-age |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-27 | 0 hypotheses
neurodegeneration | 2026-04-03 | 19 hypotheses Top: 0.891
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Discovery of an APP-selective BACE1 inhibitor for Alzheimer's disease. [PMID:40399225] | Unknown | Neurotherapeutics : the journa | 2025 | 0 |
| Discovery of an APP-selective BACE1 inhibitor for Alzheimer's disease. [PMID:40399225] | Campagna, Jagodzinska, Wi, Zhu, Lee et a | Neurotherapeutics : the journa | 2025 | 0 |
| Amyloid fibrils of the myelin basic protein are an integral component of myelin [PMID:40781105] | Sysoev EI, Shenfeld AA, Belashova TA | Sci Rep | 2025 | 0 |
| β-asarone improves cognitive impairment and alleviates autophagy in mice with va [PMID:38039902] | Ning, Zhong, Wu, Wang, Hu et al. | Phytomedicine : international | 2024 | 0 |
| Myelin basic protein mRNA levels affect myelin sheath dimensions, architecture, [PMID:39023138] | Bagheri H, Friedman H, Hadwen A | Glia | 2024 | 0 |
| β-asarone improves cognitive impairment and alleviates autophagy in mice with va [PMID:38039902] | Unknown | Phytomedicine : international | 2024 | 0 |
| Myelin basic protein and index for neuro-Behçet's disease. [PMID:36907539] | Zhan H, Cheng L, Wang X | Clin Immunol | 2023 | 0 |
| The Effect of Mindfulness-based Programs on Cognitive Function in Adults: A Syst [PMID:34350544] | Whitfield, Barnhofer, Acabchuk, Cohen, L | Neuropsychology review | 2022 | 0 |
| Multiple sclerosis and myelin basic protein: insights into protein disorder and [PMID:34889995] | Martinsen V, Kursula P | Amino Acids | 2022 | 0 |
| The Effect of Mindfulness-based Programs on Cognitive Function in Adults: A Syst [PMID:34350544] | Whitfield Tim; Barnhofer Thorsten; Acabc | Neuropsychology review | 2021 | 0 |
| An update on diagnostic and prognostic biomarkers for traumatic brain injury. [PMID:29338452] | Unknown | Expert review of molecular dia | 2019 | 0 |
| An update on diagnostic and prognostic biomarkers for traumatic brain injury. [PMID:29338452] | Unknown | Expert review of molecular dia | 2019 | 0 |
| An updated histological classification system for multiple sclerosis lesions. [PMID:27988845] | Kuhlmann T, Ludwin S, Prat A | Acta Neuropathol | 2017 | 0 |
| What do your eyes reveal about your foreign language? Reading emotional sentence [PMID:28973016] | Iacozza Sara; Costa Albert; Duñabei | PloS one | 2017 | 0 |
| What do your eyes reveal about your foreign language? Reading emotional sentence [PMID:28973016] | ["Iacozza, Sara", "Costa, Albert", "Du\u | PloS one | 2017 | 0 |
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.57 · 2026-04-28
closed · Rounds: 6 · Score: 0.83 · 2026-04-27
closed · Rounds: 4 · Score: 0.12 · 2026-04-27
closed · Rounds: 4 · Score: 0.42 · 2026-04-27
closed · Rounds: 4 · Score: 0.48 · 2026-04-27
closed · Rounds: 4 · Score: 0.47 · 2026-04-27
closed · Rounds: 4 · Score: 0.52 · 2026-04-27
closed · Rounds: 4 · Score: 0.72 · 2026-04-27
closed · Rounds: 4 · Score: 0.90 · 2026-04-03
Hypotheses and analyses mentioning myelin_breakdown in their description or question text
No additional research found