cell_type

oligodendrocytes

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about oligodendrocytes: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

900Connections

4Hypotheses

12Analyses

41Outgoing

50Incoming

No summary available yet. View on Wiki →

🧫 Cell Type Info

Cell Type	oligodendrocytes
Definition	<table class="infobox infobox-cell">
Key Markers	TAU, myelin, HSPA1A, SMS2, GPR37, PIEZO1, GBA1, Prosaposin
Key Pathways	Dna Damage Response, sphingolipid metabolism, complement cascade, pyroptosis, unfolded protein response
Associated Diseases	Alzheimer's Disease, Parkinson's Disease, aging, Alzheimer's disease, Alzheimer'S Disease, Vascular Dementia
Linked Hypotheses	112 hypotheses

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    oligodendrocytes["oligodendrocytes"] -->|"produces"| myelin["myelin"]
    style myelin fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    oligodendrocytes["oligodendrocytes"] -->|"associated"| multiple_sclerosis["multiple sclerosis"]
    style multiple_sclerosis fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    oligodendrocytes["oligodendrocytes"] -->|"associated"| neurodegeneration["neurodegeneration"]
    style neurodegeneration fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    oligodendrocytes["oligodendrocytes"] -->|"activates"| neuroinflammation["neuroinflammation"]
    style neuroinflammation fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    oligodendrocytes["oligodendrocytes"] -->|"involved in"| myelin_dysfunction["myelin dysfunction"]
    style myelin_dysfunction fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    oligodendrocytes["oligodendrocytes"] -->|"causes"| Parkinson_s_disease["Parkinson's disease"]
    style Parkinson_s_disease fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    oligodendrocytes["oligodendrocytes"] -->|"activates"| phagocytosis["phagocytosis"]
    style phagocytosis fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    neurodegeneration_1["neurodegeneration"] -->|"affects"| oligodendrocytes["oligodendrocytes"]
    style neurodegeneration_1 fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    multiple_sclerosis_2["multiple sclerosis"] -->|"affects"| oligodendrocytes["oligodendrocytes"]
    style multiple_sclerosis_2 fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    neuroinflammation_3["neuroinflammation"] -->|"affects"| oligodendrocytes["oligodendrocytes"]
    style neuroinflammation_3 fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    unfolded_protein_response["unfolded protein response"] -->|"active in"| oligodendrocytes["oligodendrocytes"]
    style unfolded_protein_response fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    aging["aging"] -->|"affects"| oligodendrocytes["oligodendrocytes"]
    style aging fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    style oligodendrocytes fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (223)

Target	Relation	Type	Str
ds-f2c28aed24a7	provides_data_for	dataset	1.00
myelin	produces	protein	0.90
multiple sclerosis	associated_with	disease	0.90
sphingolipid metabolism	active_in	pathway	0.85
Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease	involved_in	disease	0.85
multiple sclerosis	activates	disease	0.80
multiple sclerosis	inhibits	disease	0.80
neurodegeneration	associated_with	disease	0.80
NEUROINFLAMMATION	drives	process	0.80
neurodegeneration	drives	process	0.80
demyelination	implicated_in	process	0.80
unfolded protein response	active_in	pathway	0.75
neuroinflammation	activates	phenotype	0.72
neurodegeneration	activates	phenotype	0.72
multiple sclerosis	interacts_with	disease	0.70
multiple sclerosis	expressed_in	disease	0.70
multiple sclerosis	causes	disease	0.70
myelin_breakdown	vulnerable_to	pathology	0.70
oxidative stress response	active_in	pathway	0.65
autophagic alterations	associated_with	phenotype	0.65
myelin dysfunction	involved_in	biological_process	0.60
Parkinson's disease	causes	disease	0.60
neurodegeneration	causes	disease	0.60
neuroinflammation	causes	disease	0.60
Parkinson's disease	activates	disease	0.60
neurodegeneration	protects_against	disease	0.60
Parkinson's disease	expressed_in	disease	0.60
phagocytosis	activates	process	0.60
phagocytosis	expressed_in	process	0.60
ferroptosis	activates	process	0.60
ALS	associated_with	disease	0.60
amyloid aggregation	interacts_with	process	0.60
multiple sclerosis	regulates	disease	0.60
cholesterol homeostasis	active_in	pathway	0.55
neurotrophin signaling	active_in	pathway	0.55
synaptic plasticity	active_in	pathway	0.55
lipid metabolism	active_in	pathway	0.55
epigenetic regulation	active_in	pathway	0.55
insulin signaling	active_in	pathway	0.55
senescence	active_in	pathway	0.55
autophagy pathway	active_in	pathway	0.55

Incoming (677)

Source	Relation	Type	Str
ds-f2c28aed24a7	data_in	dataset	1.00
neurodegeneration	affects	disease	0.90
multiple sclerosis	affects	disease	0.90
neuroinflammation	affects	disease	0.90
unfolded protein response	active_in	pathway	0.90
aging	affects	disease	0.90
Alzheimer's disease	affects	disease	0.90
lipid metabolism	active_in	pathway	0.90
MOG	expressed_in	gene	0.90
SMS2	expressed_in	gene	0.90
FERROPTOSIS	affects	process	0.90
axon	found_in	organelle	0.90
GPR37	expressed_in	gene	0.88
OxPC	causes	chemical	0.80
complement cascade	active_in	pathway	0.80
Parkinson's disease	affects	disease	0.80
RNA	expressed_in	gene	0.80
SGMS1	associated_with	gene	0.80
SGMS1	regulates	gene	0.80
SGMS1	implicated_in	gene	0.80
NLRP3	activates	gene	0.80
pyroptosis	active_in	pathway	0.80
NLRP3	regulates	gene	0.80
AQP4	expressed_in	gene	0.80
MBP	expressed_in	gene	0.80
BIN1	expressed_in	gene	0.80
NLRP3	expressed_in	gene	0.80
SMPD1	expressed_in	gene	0.80
Piezo1	regulates	gene	0.80
DYNAMIN1	associated_with	gene	0.70
MOG	biomarker_for	gene	0.70
AQP4	activates	gene	0.70
epilepsy	affects	disease	0.70
GPR37	inhibits	gene	0.70
GPR37	protects_against	gene	0.70
LDLR	associated_with	gene	0.70
NF-kB signaling	active_in	pathway	0.70
glioblastoma	affects	disease	0.70
ferroptosis	active_in	pathway	0.70
RNA	activates	gene	0.70
PI3K-AKT-mTOR signaling	active_in	pathway	0.70
SGMS1	expressed_in	gene	0.70
SMPD1	associated_with	gene	0.70
SMPD1	regulates	gene	0.70
frontotemporal dementia	affects	disease	0.70
ALS	affects	disease	0.70
MOG	associated_with	gene	0.70
MOG	causes	gene	0.70
C3	expressed_in	gene	0.70
LDLR	expressed_in	gene	0.70

Targeting Hypotheses (4)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
PDE4 Inhibition as Inflammatory Reset for PD Oligodendrocyte	0.576	neuroinflammation	How do oligodendrocytes initiate neuroin
ACSL4-Ferroptotic Priming in Stressed Oligodendrocytes Drive	0.512	Alzheimer's Disease	Cell type vulnerability in Alzheimers Di
ACSL4-Driven Ferroptotic Priming in Disease-Associated Oligo	0.493	Alzheimer's Disease	Cell type vulnerability in Alzheimers Di
ALOX15-Driven Enzymatic Ferroptosis in AD Oligodendrocytes v	0.491	Alzheimer's Disease	Cell type vulnerability in Alzheimers Di

Mentioning Analyses (12)

Scientific analyses that reference this entity

What specific molecular mechanisms link APOE4 to cholesterol dysregulation in ol

neurodegeneration | 2026-04-14 | 1 hypotheses Top: 0.505

What molecular mechanisms enable microglia to neutralize OxPC-mediated neurodege

neuroinflammation | 2026-04-13 | 2 hypotheses Top: 0.505

How do oligodendrocytes initiate neuroinflammation in PD when microglia are trad

neuroinflammation | 2026-04-13 | 2 hypotheses Top: 0.632

What specific gene expression signatures in aging mouse white matter predict hum

neurodegeneration | 2026-04-11 | 0 hypotheses

Which cell types show the most significant expression changes for neurodegenerat

neurodegeneration | 2026-04-03 | 7 hypotheses Top: 0.529

Related Papers (6)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Vitamin C inhibits ACSL4 to alleviate ferro-aging in primates. [PMID:41819088]	Liu L, Zheng Z, You W, Yang P, Wen Y et	Cell Metab	2026
[The Chinese medicine Gandouling attenuates brain injury in hepatolenticular deg [PMID:41946579]	Wu K, Wang N, Zhao D, Wei W, Zhang W et	Zhejiang Da Xue Xue Bao Yi Xue	2026
Vitamin C slows primate aging by targeting iron-driven lipid peroxidation. [PMID:41950897]	Yu PL, Xu CR	Cell Metab	2026
The IL-33/ST2 Signaling Axis Alleviates Splenic Injury in Severe Acute Pancreati [PMID:41954769]	Cui L, Xu N, Chen J, Bin C, Feng Y et al	Pancreas	2026
Fibroblast-Specific GPX4 Deletion Exacerbates IBD via Lipid Peroxidation. [PMID:41955120]	Zhang Y, Ying Y, Huang W, Rosenfeld ZA,	Am J Physiol Gastrointest Live	2026
Isorhamnetin-preconditioned MSC-derived exosomes restore ovarian function by inh [PMID:41947243]	Zhang Q, Yu J, Zheng Y, Jiang J, Zheng L	Stem Cell Res Ther	2026

oligodendrocytes

Understanding Entity Pages

Wiki Pages (21)