Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about neuron vulnerability: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| TAU | causes | protein | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Excitatory Neuron Vulnerability via SLC17A7 Downregulation | 0.675 | alzheimers | SEA-AD Gene Expression Profiling — Allen |
| Parvalbumin Interneuron Vulnerability Links Lactate Transpor | 0.656 | neurodegeneration | What is the molecular mechanism by which |
| Layer-Specific Excitatory Neuron Vulnerability in Temporal C | 0.636 | neurodegeneration | Methodology challenge: dataset 'Allen Br |
| CCL2-CCR2 myeloid signaling as a selective driver of fast-fa | 0.626 | neurodegeneration | CCL2-CCR2 Axis at NMJ: Mechanism of Sele |
| Cell-state stratification is required to resolve CCL2-CCR2 A | 0.612 | neurodegeneration | CCL2-CCR2 Axis at NMJ: Mechanism of Sele |
| Perturbation-first validation should precede therapeutic cla | 0.608 | neurodegeneration | CCL2-CCR2 Axis at NMJ: Mechanism of Sele |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-11 | 0 hypotheses
neurodegeneration | 2026-04-02 | 5 hypotheses
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Sevoflurane aggravates hypoxic-ischemic encephalopathy in preterm neonates via V [PMID:40602692] | Qin M, Shi D, Song X, Zhang R, Feng Z, L | Brain research bulletin | 2025 | 0 |
| Audiogenic kindling activates glutamatergic system in the hippocampus of rats wi [PMID:38325559] | Aleksandrova EP, Ivlev AP, Kulikov AA, N | Brain research | 2024 | 0 |
| Alzheimer's Disease-associated Region-specific Decrease of Vesicular Glutamate T [PMID:38552733] | Wood OWG, Walby J, Yeung JH, Ke S, Palpa | Neuroscience | 2024 | 0 |
| Single-cell atlas reveals correlates of high cognitive function, dementia, and r [PMID:37774677] | Mathys H, Peng Z, Boix CA, Victor MB, Le | Cell | 2023 | 0 |
| Neurovascular dysfunction in GRN-associated frontotemporal dementia identified b [PMID:35879464] | Gerrits E, Giannini LAA, Brouwer N, Melh | Nature neuroscience | 2022 | 0 |
| Deciphering molecular interactions by proximity labeling. [PMID:33432242] | Qin W, Cho KF, Cavanagh PE, Ting AY | Nature methods | 2021 | 0 |
| Bolstering human rabies surveillance in Africa is crucial to eliminating canine- [PMID:30188896] | Anaïs Broban; Mathurin C Tejiokem; Issak | PLoS neglected tropical diseas | 2018 | 0 |
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.50 · 2026-04-20
closed · Rounds: 4 · Score: 0.88 · 2026-04-02
Hypotheses and analyses mentioning neuron vulnerability in their description or question text