Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about nucleocytoplasmic transport: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| G4C2 Repeat Expansion | associated_with | mechanism | 0.95 |
| 40970514 | show defect in | paper | 0.90 |
| TDP-43 | disrupts | protein | 0.90 |
| protein aggregates | inhibits | protein | 0.80 |
| G-Quadruplex Targeting | modulates | compound | 0.80 |
| pathological Tau | inhibits | protein | 0.70 |
| RBP pathology | disrupts | phenotype | 0.70 |
| TARDBP | regulates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| C9orf72 Hexanucleotide Repeat Dipeptide Repeat Proteins Inhi | 0.738 | neurodegeneration | Legacy Pre-Pipeline Hypothesis Import |
| C9orf72 Nucleocytoplasmic Transport Rescue for ALS/FTD | 0.597 | neurodegeneration | Test |
| RNA Metabolism and Nucleocytoplasmic Transport Defects | 0.580 | neurodegeneration | Cross-disease neurodegeneration mechanis |
| Nucleocytoplasmic Transport Disruption | 0.520 | neurodegeneration | What mechanisms underlie TDP-43's contri |
| Nuclear Pore and Nucleocytoplasmic Transport Machinery as Ga | 0.500 | neurodegeneration | What determines the specificity of RNA-p |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-01 | 13 hypotheses Top: 0.720
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.72 · 2026-04-12
closed · Rounds: 4 · Score: 0.88 · 2026-04-06
Hypotheses and analyses mentioning nucleocytoplasmic transport in their description or question text
No additional research found