entity

p-tau181

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about p-tau181: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

16Connections

0Hypotheses

2Analyses

10Outgoing

6Incoming

0Experiments

3Debates

No AI portrait yet

Wiki Pages (2)

Knowledge base pages for this entity

Phosphorylated Tau at Threonine 181 (p-tau181)

protein · 1584 words

→

Plasma p-tau181 (Phosphorylated Tau at Threonine 181)

biomarker · 1095 words

→

Outgoing (10)

Target	Relation	Type	Str
alzheimer_disease	biomarker_for	disease	0.95
alzheimers	biomarker_for	disease	0.95
Cognitive Status	associated_with	phenotype	0.90
Alzheimer's Disease	biomarker_for	disease	0.90
Alzheimer's disease	biomarker_for	disease	0.90
neurodegeneration	associated_with	disease	0.85
Mild Cognitive Impairment	biomarker_for	disease	0.82
Alzheimer's disease	biomarker_for	disease	0.80
Mild Cognitive Impairment	risk_factor_for	disease	0.78
tau pathology	biomarker_for	phenotype	0.70

Incoming (6)

Source	Relation	Type	Str
32246036	shows higher longitudinal increases than	paper	0.90
neurofibrillary tangle burden	causes	process	0.90
Lysophosphatidylcholines	associated_with	compound	0.88
Cardiovascular Risk	modulates	phenotype	0.85
Amino Acid Metabolism	associated_with	pathway	0.85
39249107	had marginal effect on	paper	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (2)

Scientific analyses that reference this entity

Does tau dendritic missorting persist independently after Aβ clearance, maintain

neurodegeneration | 2026-04-25 | 7 hypotheses Top: 0.740

What amyloid threshold level is required for optimal clinical benefit in early A

neurodegeneration | 2026-04-16 | 1 hypotheses Top: 0.577

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (3)

Multi-agent debates referencing this entity

Hypothesis debate: Multi-Biomarker Composite Index Surpassing Amyloid PET for Tr

closed · Rounds: 4 · Score: 0.50 · 2026-04-26

Does tau dendritic missorting persist independently after Aβ clearance, maintain

closed · Rounds: 4 · Score: 0.65 · 2026-04-25

While the study demonstrates dose-response relationships between amyloid levels

closed · Rounds: 4 · Score: 0.76 · 2026-04-16

Related Research

Hypotheses and analyses mentioning p-tau181 in their description or question text

No additional research found