Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about parthenolide: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| NF-κB | inhibits | pathway | 0.70 |
| extracellular_adenosine_tone | lowers | process | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Parthenolide reduces tonic ADORA2A signaling by lowering inf | 0.659 | neuropharmacology | How does parthenolide specifically modul |
| Parthenolide perturbs adenosine transport or metabolism upst | 0.506 | neuropharmacology | How does parthenolide specifically modul |
| Parthenolide enhances ADORA2A receptor internalization throu | 0.483 | neuropharmacology | How does parthenolide specifically modul |
| Parthenolide changes ADORA2A coupling efficiency through mem | 0.435 | neuropharmacology | How does parthenolide specifically modul |
Scientific analyses that reference this entity
neuropharmacology | 2026-04-25 | 4 hypotheses Top: 0.659
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Longitudinal dietary change analysis and ADRD risk over 10 years | clinical | Alzheimer's disease and relate | 0.930 | 0.00 | human patients | proposed | N/A |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
Hypotheses and analyses mentioning parthenolide in their description or question text
No additional research found