Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about proteostasis failure: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| TAU | associated_with | protein | 0.85 |
| neurodegeneration | causes (proteostasis failure leads to protein aggregation ) | disease | 0.78 |
| metabolic dysfunction | causes | mechanism | 0.70 |
| synaptic dysfunction | causes | mechanism | 0.50 |
| Aβ/tau aggregation | causes | mechanism | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| Proteasome Dysfunction | causes | process | 0.90 |
| Proteasome Downregulation | contributes_to | process | 0.90 |
| proteasome dysfunction | causes | process | 0.90 |
| proteasome dysfunction | causes (early proteasome downregulation and dysfunction dr) | mechanism | 0.78 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| TDP-43 RNA-proteostasis failure across ALS, FTD, and AD/LATE | 0.828 | multi | Cross-disease neurodegeneration mechanis |
| Autophagy-Lysosomal Pathway Dysfunction as a Unifying Proteo | 0.820 | neurodegeneration | Cross-disease neurodegeneration mechanis |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-12 | 1 hypotheses Top: 0.566
neurodegeneration | 2026-04-11 | 0 hypotheses
neurodegeneration | 2026-04-03 | 43 hypotheses Top: 0.893
neurodegeneration | 2026-04-03 | 0 hypotheses
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-lin [PMID:21944779] | Unknown | Neuron | 2011 | 0 |
| TDP-43 immunoreactivity in hippocampal sclerosis and Alzheimer's disease. [PMID:17469117] | Unknown | Annals of neurology | 2007 | 0 |
| Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic latera [PMID:17023659] | Unknown | Science (New York, N.Y.) | 2006 | 0 |
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.48 · 2026-04-21
closed · Rounds: 5 · Score: 0.67 · 2026-04-12
closed · Rounds: 4 · Score: 0.95 · 2026-04-03
closed · Rounds: 4 · Score: 0.95 · 2026-04-03
Hypotheses and analyses mentioning proteostasis failure in their description or question text
No additional research found