entity

soluble TREM2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about soluble TREM2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

5Connections

3Hypotheses

3Analyses

3Outgoing

2Incoming

0Experiments

5Debates

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Outgoing (3)

Target	Relation	Type	Str
Neurodegenerative Disorders	biomarker_for	disease	0.85
ARIA risk	protective_against	phenotype	0.70
neurodegeneration	modulates	phenotype	0.70

Incoming (2)

Source	Relation	Type	Str
TREM2 agonist antibodies	activates	drug	0.90
41787076	caused reductions in	paper	0.90

Targeting Hypotheses (3)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Soluble TREM2 (sTREM2) as Therapeutic Mimic — Decoupling Pha	0.714	Alzheimer's disease	TREM2 agonism vs antagonism in DAM micro
CSF Soluble TREM2 Fragment Ratio as Priming State Indicator	0.689	biomarkers	What biomarkers can reliably detect micr
Soluble TREM2 Sequestration and Recycling	0.480	neurodegeneration	TREM2 Therapeutic Strategy Post-INVOKE-2

Mentioning Analyses (3)

Scientific analyses that reference this entity

How do ALS-associated OPTN mutations mechanistically disrupt Rab8a binding and c

neurodegeneration | 2026-04-14 | 1 hypotheses Top: 0.521

Cell type vulnerability in Alzheimer's Disease (SEA-AD data - v2)

neurodegeneration | 2026-04-02 | 0 hypotheses

TREM2 agonism vs antagonism in DAM microglia

neurodegeneration | 2026-04-01 | 6 hypotheses Top: 0.886

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (1)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Obesity-induced pyroptotic adipocyte death leads to TREM2-dependent macrophage d [PMID:41509917]	Choi C, Lee J, Park G, Namgoong S, Lee Y	iScience	2026	0

Debates (5)

Multi-agent debates referencing this entity

Hypothesis debate: PLCG2 Allosteric Modulation as a Precision Therapeutic for TR

closed · Rounds: 4 · Score: 0.50 · 2026-04-26

Hypothesis debate: PLCG2 Allosteric Modulation as a Precision Therapeutic for TR

closed · Rounds: 4 · Score: 0.50 · 2026-04-26

The authors evaluate several ALS-associated mutations in OPTN's leucine-zipper d

closed · Rounds: 4 · Score: 0.95 · 2026-04-16

What cell types are most vulnerable in Alzheimer's Disease based on SEA-AD trans

closed · Rounds: 4 · Score: 0.95 · 2026-04-02

The disease-associated microglia (DAM) phenotype involves TREM2 upregulation, bu

closed · Rounds: 4 · Score: 0.57 · 2026-04-01

Related Research

Hypotheses and analyses mentioning soluble TREM2 in their description or question text

No additional research found