Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about sphingosine-1-phosphate: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| Neuroinflammation | causes | process | 0.90 |
| NF-ΚB | activates | protein | 0.90 |
| Macrophage Infiltration | causes | process | 0.85 |
| Experimental Autoimmune Encephalomyelitis | contributes_to | disease | 0.85 |
| Glia | expressed_in | cell_type | 0.85 |
| amyloid-beta pathology | suppresses | phenotype | 0.75 |
| Source | Relation | Type | Str |
|---|---|---|---|
| Vlcfa | associated_with | compound | 0.95 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Sphingosine-1-Phosphate Gradient Disruption | 0.455 | neuroinflammation | Why do clinical manifestations overlap d |
| Ceramide-Sphingosine-1-Phosphate Axis Rebalancing via SPHK1 | 0.000 | - | Lipid metabolism dysregulation and membr |
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning sphingosine-1-phosphate in their description or question text
No additional research found