Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Neuroinflammation: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Neuroinflammation is a biological process related to neurodegeneration research. Key relationships include: activates, regulates, therapeutic target. Associated with Aging, Als, Alzheimer. Connected to 2105 entities in the SciDEX knowledge graph.
| Name | Neuroinflammation |
| Related Diseases | Inflammation, Parkinson |
| Related Pathways | Nf-Κb, Complement, Phagocytosis, Blood-Brain Barrier, Oxidative Stress |
| Linked Hypotheses | 6 hypotheses |
Knowledge base pages for this entity
graph TD
subgraph Signaling["Signaling"]
Neuroinflammation["Neuroinflammation"] -->|"activates"| Nf__b["Nf-Kappab"]
Neuroinflammation["Neuroinflammation"] -->|"activates"| Complement["Complement"]
Neuroinflammation["Neuroinflammation"] -->|"activates"| Phagocytosis["Phagocytosis"]
Neuroinflammation["Neuroinflammation"] -.->|"inhibits"| Nf__b_1["Nf-Kappab"]
TREM2["TREM2"] -->|"activates"| Neuroinflammation["Neuroinflammation"]
TNF["TNF"] -.->|"inhibits"| Neuroinflammation["Neuroinflammation"]
NRF2["NRF2"] -->|"activates"| Neuroinflammation["Neuroinflammation"]
TNF_3["TNF"] -->|"activates"| Neuroinflammation["Neuroinflammation"]
end
subgraph Pathology["Pathology"]
Neuroinflammation["Neuroinflammation"] -->|"associated with"| Inflammation["Inflammation"]
Neuroinflammation["Neuroinflammation"] -->|"associated with"| Parkinson["Parkinson"]
Neuroinflammation["Neuroinflammation"] -->|"associated with"| Oxidative_Stress["Oxidative Stress"]
Neuroinflammation["Neuroinflammation"] -->|"associated with"| Blood_Brain_Barrier_2["Blood-Brain Barrier"]
GFAP["GFAP"] -->|"biomarker for"| Neuroinflammation["Neuroinflammation"]
end
subgraph Therapeutic["Therapeutic"]
Neuroinflammation["Neuroinflammation"] -->|"therapeutic target"| Blood_Brain_Barrier["Blood-Brain Barrier"]
OVERVIEW["OVERVIEW"] -->|"therapeutic target"| Neuroinflammation["Neuroinflammation"]
end
style Neuroinflammation fill:#1b5e20,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0,font-weight:bold
style Nf__b fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Complement fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Phagocytosis fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Nf__b_1 fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Inflammation fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Blood_Brain_Barrier fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Parkinson fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Oxidative_Stress fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Blood_Brain_Barrier_2 fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style TREM2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style OVERVIEW fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style TNF fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style NRF2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style TNF_3 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style GFAP fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Nf-Κb | activates | pathway | 1.00 |
| Complement | activates | pathway | 1.00 |
| Phagocytosis | activates | pathway | 1.00 |
| Nf-Κb | inhibits | pathway | 1.00 |
| Inflammation | associated_with | disease | 1.00 |
| Blood-Brain Barrier | therapeutic_target | pathway | 1.00 |
| Parkinson | associated_with | disease | 1.00 |
| Oxidative Stress | associated_with | pathway | 1.00 |
| Blood-Brain Barrier | associated_with | pathway | 1.00 |
| Toll-Like Receptor | activates | pathway | 1.00 |
| Oxidative Stress | activates | pathway | 1.00 |
| Oxidative Stress | therapeutic_target | pathway | 1.00 |
| Apoptosis | activates | pathway | 1.00 |
| Inflammasome | activates | pathway | 1.00 |
| Blood-Brain Barrier | activates | pathway | 1.00 |
| Autophagy | activates | pathway | 1.00 |
| Mitophagy | activates | pathway | 1.00 |
| Immune Response | activates | pathway | 1.00 |
| Mapk | activates | pathway | 1.00 |
| Mtor | activates | pathway | 1.00 |
| Synaptic Plasticity | activates | pathway | 1.00 |
| Immune Response | therapeutic_target | pathway | 1.00 |
| Neurodegeneration | activates | process | 1.00 |
| Inflammation | regulates | disease | 1.00 |
| Neurodegeneration | causes | disease | 1.00 |
| Inflammation | causes | disease | 1.00 |
| Inflammation | activates | disease | 1.00 |
| Parkinson | activates | disease | 1.00 |
| Als | activates | disease | 1.00 |
| Inflammation | therapeutic_target | disease | 1.00 |
| Alzheimer | treats | disease | 1.00 |
| Dementia | activates | disease | 1.00 |
| Inflammation | inhibits | disease | 1.00 |
| Pi3K/Akt | activates | pathway | 1.00 |
| Depression | activates | disease | 1.00 |
| Alzheimer | regulates | disease | 1.00 |
| Neurodegeneration | regulates | disease | 1.00 |
| Alzheimer | activates | disease | 1.00 |
| Inflammation | contributes_to | disease | 1.00 |
| Neurodegeneration | implicated_in | disease | 1.00 |
| Alzheimer | associated_with | disease | 1.00 |
| Inflammation | interacts_with | disease | 1.00 |
| Alzheimer | therapeutic_target | disease | 1.00 |
| Neurodegeneration | therapeutic_target | disease | 1.00 |
| Dementia | therapeutic_target | disease | 1.00 |
| Als | therapeutic_target | disease | 1.00 |
| Stroke | activates | disease | 1.00 |
| Inflammation | implicated_in | disease | 1.00 |
| Alzheimer | contributes_to | disease | 1.00 |
| Alzheimer | causes | disease | 1.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| TREM2 | activates | gene | 1.00 |
| OVERVIEW | therapeutic_target | gene | 1.00 |
| TNF | inhibits | gene | 1.00 |
| NRF2 | activates | gene | 1.00 |
| TNF | activates | gene | 1.00 |
| GFAP | biomarker_for | gene | 1.00 |
| TLR4 | activates | gene | 1.00 |
| BDNF | activates | gene | 1.00 |
| NLRP3 | activates | gene | 1.00 |
| GFAP | activates | gene | 1.00 |
| APOE | regulates | gene | 1.00 |
| GENES | activates | gene | 1.00 |
| Als | associated_with | disease | 1.00 |
| Parkinson | associated_with | disease | 1.00 |
| GENES | regulates | gene | 1.00 |
| AMPK | activates | gene | 1.00 |
| Aging | associated_with | disease | 1.00 |
| PINK1 | activates | gene | 1.00 |
| DNA | therapeutic_target | gene | 1.00 |
| DNA | activates | gene | 1.00 |
| STING | activates | gene | 1.00 |
| CGAS | activates | gene | 1.00 |
| APP | activates | gene | 1.00 |
| MTOR | activates | gene | 1.00 |
| AKT | activates | gene | 1.00 |
| GENES | therapeutic_target | gene | 1.00 |
| PARKIN | activates | gene | 1.00 |
| STAT3 | activates | gene | 1.00 |
| TREM2 | therapeutic_target | gene | 1.00 |
| PI3K | activates | gene | 1.00 |
| BCL-2 | activates | gene | 1.00 |
| BAX | activates | gene | 1.00 |
| NLRP3 | inhibits | gene | 1.00 |
| PI3K | therapeutic_target | gene | 1.00 |
| AKT | therapeutic_target | gene | 1.00 |
| SIRT1 | activates | gene | 1.00 |
| NEUROINFLAMMATION | associated_with | gene | 1.00 |
| MITOPHAGY | activates | gene | 1.00 |
| CYTOKINES | activates | gene | 1.00 |
| PROINFLAMMATORY CYTOKINES | activates | gene | 1.00 |
| MITOCHONDRIAL DYSFUNCTION | activates | gene | 1.00 |
| AUTOPHAGY | activates | gene | 1.00 |
| NEUROINFLAMMATION | activates | gene | 1.00 |
| PARKINSON'S DISEASE | activates | gene | 1.00 |
| MICROGLIA | activates | gene | 1.00 |
| AGING | activates | gene | 1.00 |
| INFLAMMATION | activates | gene | 1.00 |
| MICROGLIA | therapeutic_target | gene | 1.00 |
| PHAGOCYTOSIS | activates | gene | 1.00 |
| ALZHEIMER'S DISEASE | therapeutic_target | gene | 1.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Beta-Hydroxybutyrate Receptor (HCAR2) Signaling Links Ketone | 0.645 | neurodegeneration | What are the precise temporal dynamics o |
| STING Antagonism Prevents Acute-to-Chronic Neuroinflammation | 0.605 | neuroinflammation | What molecular mechanisms drive the tran |
| Microglial AIM2 Inflammasome as the Primary Driver of TDP-43 | 0.601 | neurodegeneration | What are the mechanisms by which gut mic |
| Lactate/Pyruvate Ratio Dynamics in CSF as a Neuroinflammatio | 0.486 | translational neuroscience | Which metabolic biomarkers can distingui |
| Cardiovascular-Neuroinflammation Crosstalk Interruption | 0.437 | Alzheimer's disease | Neuroinflammation and microglial priming |
Scientific analyses that reference this entity
neuroinflammation | 2026-04-15 | 2 hypotheses Top: 0.605
neuroinflammation | 2026-04-13 | 2 hypotheses Top: 0.632
neurodegeneration | 2026-04-13 | 2 hypotheses Top: 0.473
neurodegeneration | 2026-04-13 | 1 hypotheses Top: 0.584
neurodegeneration | 2026-04-11 | 0 hypotheses
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Complement C1q-Targeted Microglial Membrane Camouflaged Nanolipid Carriers for S [PMID:41114949] | Ding YN, Li MQ, Ding PT, Wang P, Guan PP | Nano letters | 2026 | 1 |
| Systemic inflammation as a central player in the initiation and development of A [PMID:40841660] | Bayraktaroglu I, Ortí-Casañ N, Van Dam D | Immunity & ageing : I & A | 2025 | 1 |
| Cerium-doped Prussian blue biomimetic nanozyme as an amplified pyroptosis inhibi [PMID:40050873] | Ma J, Tian Y, Du C, Zhu Y, Huang W, Ding | Journal of nanobiotechnology | 2025 | 1 |
| Interactions between antidiabetes medications and heart-brain axis. [PMID:39639832] | Ong LT, Sia CH | Current opinion in endocrinolo | 2025 | 1 |
| The Molecular Mechanisms of Cognitive Dysfunction in Long COVID: A Narrative Rev [PMID:40507911] | Popa E, Popa AE, Poroch M, Poroch V, Ung | International journal of molec | 2025 | 1 |
| Air pollution, glymphatic impairment, and Alzheimer's disease. [PMID:37777345] | Hussain R, Graham U, Elder A, Nedergaard | Trends in neurosciences | 2023 | 0 |
| Molecular biomarkers for vascular cognitive impairment and dementia. [PMID:37957261] | Hosoki S, Hansra GK, Jayasena T, Poljak | Nature reviews. Neurology | 2023 | 0 |