Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about syndecan_1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| endothelial_glycocalyx | maintains | structure | 0.80 |
| Source | Relation | Type | Str |
|---|---|---|---|
| SDC1 | encodes | gene | 0.80 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Endothelial Glycocalyx Regeneration via Syndecan-1 Upregulat | 0.505 | neurodegeneration | Perivascular spaces and glymphatic clear |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.623
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| NETs induce ferroptosis of endothelial cells in LPS-ALI through SDC-1/HS and dow [PMID:38677244] | Fei Y, Huang X, Ning F, Qian T, Cui J, W | Biomed Pharmacother | 2024 | 1 |
| Protectin conjugates in tissue regeneration 1 restores lipopolysaccharide-induce [PMID:34217286] | Wang XY, Li XY, Wu CH, Hao Y, Fu PH, Mei | Respir Res | 2021 | 1 |
| The glycocalyx: a novel diagnostic and therapeutic target in sepsis. [PMID:30654825] | Uchimido R, Schmidt EP, Shapiro NI | Crit Care | 2019 | 1 |
| Pathogenic Significance of Serum Syndecan-1 and Syndecan-4 in Psoriasis. [PMID:41839009] | Yıldırım MA, Korkmaz S, Çelik HHA, Büyük | Cutis | 2026 | 0 |
| CD138 expression in the endometrium associates with endometrial timing and infla [PMID:41858134] | Odendaal J, Fishwick K, Correia GDS, Lee | Human reproduction (Oxford, En | 2026 | 0 |
| [Multicenter prospective study on the diagnostic value of syndecan-1 for necroti [PMID:41914411] | Yin XY, Zhao ZH, Wang Y, Cai N, Chen S | Zhongguo dang dai er ke za zhi | 2026 | 0 |
| Association of Viraemic Phase Viral Load, Antibody Responses, and Immune Biomark [PMID:41891425] | Alagarasu K, Gurav YK, Pulinchani A, Bac | Journal of medical virology | 2026 | 0 |
| Effect of Normothermic Machine Perfusion on Glycocalyx Shedding During Liver Tra [PMID:41847595] | Mathis S, Putzer G, Gasteiger L, Staier | Transplant international : off | 2026 | 0 |
| Ageing alters the lipid sensing process in the hypothalamus of Wistar rats. Effe [PMID:33544062] | ["Rodr\u00edguez M", "Pintado C", "Torri | Nutritional neuroscience | 2022 | 0 |
| Syndecan-1 promotes lung fibrosis by regulating epithelial reprogramming through [PMID:31393853] | ["Parimon T", "Yao C", "Habiel D", "Ge L | JCI insight | 2019 | 0 |
| Teacher development: a patchwork-text approach to enhancing critical reflection [PMID:24589866] | ["Silva-Fletcher A", "May H", "Magnier K | Journal of veterinary medical | 2014 | 0 |
| Genetics and phosphoproteomics reveal a protein phosphorylation network in the a [PMID:23572148] | ["Umezawa T", "Sugiyama N", "Takahashi F | Science signaling | 2013 | 0 |
| Epidemic and intervention modelling--a scientific rationale for policy decisions [PMID:22511828] | ["Van Kerkhove M", "Ferguson N"] | Bulletin of the World Health O | 2012 | 0 |
| Identification of novel substrates for human cytochrome P450 2J2. [PMID:19923256] | ["Lee C", "Neul D", "Clouser-Roche A", " | Drug metabolism and dispositio | 2010 | 0 |
| Distribution and prevalence of leukocyte phenotypes in brains of lupus-prone mic [PMID:16904195] | ["Ma X", "Foster J", "Sakic B"] | Journal of neuroimmunology | 2006 | 0 |