concept

SDC1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SDC1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

203Connections

1Hypotheses

1Analyses

50Outgoing

50Incoming

Summary

SDC1 is a concept in neurodegeneration research. Key relationships include: associated with, co discussed, expressed in. Associated with Als, Cancer, Carcinoma. Connected to 63 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	SDC1
Key Genes/Proteins	TGM2, HGF, syndecan_1
Related Diseases	Radioresistance, Glioblastoma Multiforme, radioresistance

🔮 Predicted Structure: SDC1 — AlphaFold H7C1K4 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (14)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    SDC1["SDC1"]
    SDC1 -->|"involved_in"| Ferroptosis["Ferroptosis"]
    SDC1 -.biomarker for.-> glioblastoma_multiforme["glioblastoma multiforme"]
    SDC1 -->|"activates"| radioresistance["radioresistance"]
    SDC1 -->|"regulates"| radiotherapy["radiotherapy"]
    SDC1 -->|"regulates"| Tumor["Tumor"]
    SDC1 -->|"interacts"| Als["Als"]
    SDC1 -->|"interacts"| Ms["Ms"]
    SDC1 -->|"expressed in"| Carcinoma["Carcinoma"]
    SDC1 -->|"expressed in"| Cancer["Cancer"]
    h_fb56c8a0["h-fb56c8a0"] -->|"targets"| SDC1
    MMP1["MMP1"] -->|"expressed in"| SDC1
    CANCER["CANCER"] -->|"expressed in"| SDC1

Outgoing (113)

Target	Relation	Type	Str
TGM2	interacts_with	protein	0.95
Radioresistance	contributes_to	phenotype	0.92
LYSOSOME	translocates_to	entity	0.90
HGF	interacts_with	gene	0.90
Glioblastoma Multiforme	biomarker_for	disease	0.85
radioresistance	promotes	phenotype	0.85
Ferroptosis	involved_in	process	0.85
TGM2	binds	gene	0.80
Heparan Sulfate	expressed_in	compound	0.80
Autophagosome	transports	cellular_component	0.80
syndecan_1	encodes	protein	0.80
endothelial glycocalyx	involved_in	process	0.75
radioresistance	associated_with	process	0.70
glioblastoma multiforme	biomarker_for	disease	0.70
radioresistance	activates	process	0.70
glioblastoma multiforme	associated_with	disease	0.70
radiotherapy	regulates	process	0.70
TGM2	transported_by	gene	0.70
Glioblastoma	associated_with	disease	0.65
Tumor	associated_with	disease	0.65
Tumor	regulates	disease	0.65
Als	interacts_with	disease	0.65
Ms	interacts_with	disease	0.65
Carcinoma	expressed_in	disease	0.65
Cancer	expressed_in	disease	0.65
Tumor	expressed_in	disease	0.65
Glioblastoma	regulates	disease	0.65
neurodegeneration	associated_with	disease	0.63
TGM2	associated_with	gene	0.60
P62	associated_with	gene	0.60
SNAP29	associated_with	gene	0.60
STX17	associated_with	gene	0.60
LAMP2	associated_with	gene	0.60
VAMP8	associated_with	gene	0.60
EPG5	associated_with	gene	0.60
LC3	associated_with	gene	0.60
GBM	associated_with	gene	0.60
SPP1	expressed_in	gene	0.60
SQSTM1	associated_with	gene	0.60
neurodegeneration	implicated_in	disease	0.60
EPG5	regulates	gene	0.60
TGM2	mediates	entity	0.60
TGM2	expressed_in	entity	0.60
TGM2	activates	entity	0.60
SNAP29	interacts_with	entity	0.60
STX17	interacts_with	entity	0.60
VAMP8	interacts_with	entity	0.60
TGM2	therapeutic_target	entity	0.60
SNAP29	regulates	entity	0.60
SQSTM1	regulates	entity	0.60

Incoming (90)

Source	Relation	Type	Str
h-fb56c8a0	targets_gene	hypothesis	0.90
h-fb56c8a0	targets	hypothesis	0.80
Nets	downregulates	process	0.80
NETs	suppresses	process	0.80
VAMP8	associated_with	gene	0.60
LAMP2	associated_with	gene	0.60
GBM	associated_with	gene	0.60
LC3	associated_with	gene	0.60
EPG5	associated_with	gene	0.60
STX17	associated_with	gene	0.60
SQSTM1	associated_with	gene	0.60
SNAP29	associated_with	gene	0.60
CD4	associated_with	gene	0.60
MMP1	expressed_in	gene	0.60
CD8	associated_with	gene	0.60
P62	associated_with	gene	0.60
TGM2	associated_with	gene	0.60
GBM	expressed_in	gene	0.60
TGM2	regulates	gene	0.60
EPG5	mediates	entity	0.60
GBM	activates	entity	0.60
EPG5	interacts_with	entity	0.60
LC3	interacts_with	entity	0.60
EPG5	therapeutic_target	entity	0.60
GBM	therapeutic_target	entity	0.60
EPG5	regulates	entity	0.60
GBM	regulates	entity	0.60
LAMP2	regulates	entity	0.60
LC3	regulates	entity	0.60
P62	regulates	entity	0.60
GBM	implicated_in	gene	0.60
GBM	inhibits	gene	0.60
GBM	interacts_with	gene	0.60
EPG5	binds_to	gene	0.60
LC3	transported_by	gene	0.60
FLOT1	associated_with	gene	0.60
GBM	treats	gene	0.60
FLOT1	interacts_with	gene	0.60
FLOT1	transported_by	gene	0.60
FLOT1	activates	gene	0.60
FLOT1	implicated_in	gene	0.60
CANCER	expressed_in	gene	0.60
GFP	associated_with	gene	0.60
MAP1LC3	associated_with	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
GLIOBLASTOMA	associated_with	gene	0.60
AND	expressed_in	gene	0.60
MAP1LC3	regulates	gene	0.60
GFP	regulates	gene	0.60
GFP	interacts_with	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Endothelial Glycocalyx Regeneration via Syndecan-1 Upregulat	0.505	neurodegeneration	Perivascular spaces and glymphatic clear

Mentioning Analyses (1)

Scientific analyses that reference this entity

Perivascular spaces and glymphatic clearance failure in AD

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.623

Related Papers (15)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
NETs induce ferroptosis of endothelial cells in LPS-ALI through SDC-1/HS and dow [PMID:38677244]	Fei Y, Huang X, Ning F, Qian T, Cui J, W	Biomed Pharmacother	2024	1
Protectin conjugates in tissue regeneration 1 restores lipopolysaccharide-induce [PMID:34217286]	Wang XY, Li XY, Wu CH, Hao Y, Fu PH, Mei	Respir Res	2021	1
The glycocalyx: a novel diagnostic and therapeutic target in sepsis. [PMID:30654825]	Uchimido R, Schmidt EP, Shapiro NI	Crit Care	2019	1
Pathogenic Significance of Serum Syndecan-1 and Syndecan-4 in Psoriasis. [PMID:41839009]	Yıldırım MA, Korkmaz S, Çelik HHA, Büyük	Cutis	2026	0
CD138 expression in the endometrium associates with endometrial timing and infla [PMID:41858134]	Odendaal J, Fishwick K, Correia GDS, Lee	Human reproduction (Oxford, En	2026	0
[Multicenter prospective study on the diagnostic value of syndecan-1 for necroti [PMID:41914411]	Yin XY, Zhao ZH, Wang Y, Cai N, Chen S	Zhongguo dang dai er ke za zhi	2026	0
Association of Viraemic Phase Viral Load, Antibody Responses, and Immune Biomark [PMID:41891425]	Alagarasu K, Gurav YK, Pulinchani A, Bac	Journal of medical virology	2026	0
Effect of Normothermic Machine Perfusion on Glycocalyx Shedding During Liver Tra [PMID:41847595]	Mathis S, Putzer G, Gasteiger L, Staier	Transplant international : off	2026	0
Ageing alters the lipid sensing process in the hypothalamus of Wistar rats. Effe [PMID:33544062]	["Rodr\u00edguez M", "Pintado C", "Torri	Nutritional neuroscience	2022	0
Syndecan-1 promotes lung fibrosis by regulating epithelial reprogramming through [PMID:31393853]	["Parimon T", "Yao C", "Habiel D", "Ge L	JCI insight	2019	0
Teacher development: a patchwork-text approach to enhancing critical reflection [PMID:24589866]	["Silva-Fletcher A", "May H", "Magnier K	Journal of veterinary medical	2014	0
Genetics and phosphoproteomics reveal a protein phosphorylation network in the a [PMID:23572148]	["Umezawa T", "Sugiyama N", "Takahashi F	Science signaling	2013	0
Epidemic and intervention modelling--a scientific rationale for policy decisions [PMID:22511828]	["Van Kerkhove M", "Ferguson N"]	Bulletin of the World Health O	2012	0
Identification of novel substrates for human cytochrome P450 2J2. [PMID:19923256]	["Lee C", "Neul D", "Clouser-Roche A", "	Drug metabolism and dispositio	2010	0
Distribution and prevalence of leukocyte phenotypes in brains of lupus-prone mic [PMID:16904195]	["Ma X", "Foster J", "Sakic B"]	Journal of neuroimmunology	2006	0

SDC1

Understanding Entity Pages

Summary

Wiki Pages (14)

Section 99: Purinergic Signaling and P2X/P2Y Receptors in CBS/PSP

ASC (PYCARD)

RAN Gene

VAMP8 — Vesicle Associated Membrane Protein 8

FGF6 Gene

Section 226: Proteoglycan and Basement Membrane Therapy in CBS/PSP

Intravenous Immunoglobulin (IVIG)

Clinical Trials

ACE Protein

B4GALT7 — Beta-1,4-Galactosyltransferase 7

ACE Gene

Ephrin Signaling Modulation Therapy

VEGF and Angiogenesis Therapy