entity

trained_immunity

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about trained_immunity: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

7Connections

6Hypotheses

2Analyses

1Outgoing

6Incoming

0Experiments

2Debates

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Outgoing (1)

Target	Relation	Type	Str
Microglial Metabolic Reprogramming	regulates	phenotype	0.70

Incoming (6)

Source	Relation	Type	Str
C1Q	inhibits	protein	0.72
SIRT1	associated_with	gene	0.70
mevalonate_pathway	regulates	pathway	0.70
pathological protein aggregates	causes	phenotype	0.70
BCG	activates	drug	0.56
beta_glucan	activates	drug	0.56

Targeting Hypotheses (6)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
TGF-β1–SMAD2/3 Axis as Master Suppressor of Microglial Train	0.712	neuroinflammation	What specific astrocyte-derived factors
LPS-primed microglial trained immunity establishes persisten	0.670	neurodegeneration	Synaptic pruning by microglia in neurode
Microglial Metabolic Trained Immunity via mTOR-HIF1α Axis	0.644	developmental-neurobiology	Do perinatal immune challenges create pe
Astrocytic Metabolic Trained Immunity via AMPK-PGC1α Axis	0.380	developmental-neurobiology	Do perinatal immune challenges create pe
Astrocytic Metabolic Trained Immunity via AMPK-PGC1α Axis	0.351	developmental-neurobiology	Do perinatal immune challenges create pe

Trained Immunity Metabolic Reset	0.000	-	Metabolic reprogramming in neurodegenera

Mentioning Analyses (2)

Scientific analyses that reference this entity

What specific astrocyte-derived factors can 'erase' pathological microglial memo

neuroinflammation | 2026-04-08 | 5 hypotheses Top: 0.712

Metabolic reprogramming in neurodegenerative disease

neurodegeneration | 2026-04-02 | 6 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (2)

Multi-agent debates referencing this entity

The astrocyte-mediated hypothesis proposes memory erasure but provides no molecu

closed · Rounds: 4 · Score: 0.65 · 2026-04-21

closed · Rounds: 4 · Score: 0.95 · 2026-04-15

Related Research

Hypotheses and analyses mentioning trained_immunity in their description or question text

Trained Immunity Metabolic Reset

Score: 0.000 · unknown disease · 2026-04-28

Pathological protein aggregates induce a form of trained immunity in microglia through metabolic reprogramming that pers