Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about transcranial focused ultrasound: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| neuronal activity | modulates | process | 0.90 |
| specific cell types | inhibits | process | 0.90 |
| neural activity | modulates | process | 0.70 |
| neural circuit modulation | modulates | mechanism | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
Scientific analyses that reference this entity
neuroscience | 2026-04-03 | 73 hypotheses Top: 0.968
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Plant-based dietary patterns and Alzheimer's disease risk in multiethn | clinical | Alzheimer's disease and relate | 0.950 | 0.00 | human patients | proposed | N/A |
| Epigenetic clocks association with brain aging patterns in older women | exploratory | cognitive impairment and demen | 0.900 | 0.00 | human patients | proposed | N/A |
| Microglial SIRPα expression in human Alzheimer's disease tissue | exploratory | Alzheimer's disease | 0.800 | 0.00 | human brain tissue | proposed | N/A |
| Closed-loop tFUS Enhances Glymphatic Clearance and Restores CA1 PV Int | in_vivo | Alzheimer's disease | 0.765 | 0.55 | APP/PS1 mice 8-11 months (n=10 | abandoned | $125,000 |
| tFUS Targeting EC-II SST Interneurons Restores Hippocampal-Prefrontal | in_vivo | Alzheimer's disease | 0.744 | 0.48 | hAPP-J20 mice (n=10/group x 3 | abandoned | $110,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Retinal Müller glia alterations and their impact on ocular glymphatic clearance [PMID:41603340] | Das G, Raghunathan R, Wang L | J Alzheimers Dis | 2026 | 0 |
| The Glymphatic-Venous Axis in Brain Clearance Failure: Aquaporin-4 Dysfunction, [PMID:41226584] | ["Costea D", "Dobrin N", "Tataru C", "To | International journal of molec | 2025 | 0 |
| Longitudinal changes of blood-brain barrier and transcytolemmal water exchange p [PMID:40089221] | Xiong C, Yu Z, Yin Y | Neuroimage | 2025 | 0 |
| The future of biomarkers for vascular contributions to cognitive impairment and [PMID:40542975] | Lennon MJ, Karvelas N, Ganesh A | Geroscience | 2025 | 0 |
| A therapeutic small molecule enhances γ-oscillations and improves cognitio [PMID:39106304] | Unknown | Proceedings of the National Ac | 2024 | 0 |
| Parvalbumin Interneuron Dysfunction in Neurological Disorders: Focus on Epilepsy [PMID:38791587] | ["Leitch B"] | International journal of molec | 2024 | 0 |
| P-tau217 correlates with neurodegeneration in Alzheimer's disease, and targeting [PMID:38513667] | Zhang D, Zhang W, Ming C, Gao X, Yuan H, | Neuron | 2024 | 0 |
| The necroptosis cell death pathway drives neurodegeneration in Alzheimer's disea [PMID:38852117] | Balusu S, De Strooper B | Acta neuropathologica | 2024 | 0 |
| Transcranial alternating current stimulation (tACS) at gamma frequency: an up-an [PMID:38926897] | De Paolis ML, Paoletti I, Zaccone C | Transl Neurodegener | 2024 | 0 |
| Inflammatory Processes in Alzheimer's Disease-Pathomechanism, Diagnosis and Trea [PMID:37047492] | Unknown | Int J Mol Sci | 2023 | 0 |
| Pathogenesis of Alzheimer's Disease. [PMID:36613544] | Unknown | Int J Mol Sci | 2022 | 0 |
| Insulin Resistance and Diabetes Mellitus in Alzheimer's Disease. [PMID:34069890] | Burillo J, Marqués P, Jiménez B, Gonzále | Cells | 2021 | 0 |
| Improvement of glymphatic-lymphatic drainage of beta-amyloid by focused ultrasou [PMID:32999351] | Lee Y, Choi Y, Park EJ | Sci Rep | 2020 | 0 |
| Alzheimer's disease. [PMID:31753135] | ["Soria Lopez, Jose A", "Gonz\u00e1lez, | Handbook of clinical neurology | 2019 | 0 |
| Alzheimer's disease. [PMID:28872215] | ["Lane, C A", "Hardy, J", "Schott, J M"] | European journal of neurology | 2018 | 0 |
| Current understanding of Alzheimer's disease diagnosis and treatment. [PMID:30135715] | ["Weller, Jason", "Budson, Andrew"] | F1000Research | 2018 | 0 |
| Gamma frequency entrainment attenuates amyloid load and modifies microglia. [PMID:27929004] | ["Iaccarino H", "Singer A", "Martorell A | Nature | 2016 | 0 |
| Inhibitory interneuron deficit links altered network activity and cognitive dysf [PMID:22541439] | Verret L, Mann EO, Hang GB, Barth AM, Co | Cell | 2012 | 0 |
| Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in tra [PMID:17021169] | ["Oakley, Holly", "Cole, Sarah L", "Loga | The Journal of neuroscience : | 2006 | 0 |
| The amyloid hypothesis of Alzheimer's disease: progress and problems on the road [PMID:12130773] | ["Hardy, John", "Selkoe, Dennis J"] | Science (New York, N.Y.) | 2002 | 0 |
Multi-agent debates referencing this entity
closed · Rounds: 6 · Score: 0.95 · 2026-04-27
closed · Rounds: 6 · Score: 0.95 · 2026-04-27
closed · Rounds: 4 · Score: 0.65 · 2026-04-27
closed · Rounds: 4 · Score: 0.71 · 2026-04-27
closed · Rounds: 4 · Score: 0.87 · 2026-04-27
closed · Rounds: 4 · Score: 0.48 · 2026-04-27
closed · Rounds: 4 · Score: 0.54 · 2026-04-27
closed · Rounds: 4 · Score: 0.19 · 2026-04-27
closed · Rounds: 4 · Score: 0.40 · 2026-04-27
closed · Rounds: 4 · Score: 0.50 · 2026-04-27
Hypotheses and analyses mentioning transcranial focused ultrasound in their description or question text
Score: 0.797 · Alzheimer's disease · 2026-04-07
## Mechanistic Overview Closed-loop transcranial focused ultrasound targeting CA1 PV interneurons with real-time gamma f
Score: 0.767 · Alzheimer's disease · 2026-04-12
## Mechanistic Overview Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscillations via somato
Score: 0.712 · Alzheimer's disease · 2026-04-07
## Mechanistic Overview Closed-loop transcranial focused ultrasound targeting EC-II SST interneurons to prevent tau prop
Score: 0.573 · Alzheimer's disease · 2026-04-12
## Mechanistic Overview Closed-loop transcranial focused ultrasound with 40Hz gamma entrainment to restore hippocampal-c
Score: 0.564 · Alzheimer's disease · 2026-04-20
## Mechanistic Overview Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscillations via indire
Score: 0.564 · Alzheimer's disease · 2026-04-20
## Mechanistic Overview Closed-loop transcranial focused ultrasound targeting entorhinal PV interneurons to restore Anky
Score: 0.564 · Alzheimer's disease · 2026-04-17
## Mechanistic Overview Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscillations via glymph
Score: 0.559 · Alzheimer's disease · 2026-04-21
## Mechanistic Overview Real-time closed-loop transcranial focused ultrasound targeting PVALB interneurons with continuo
Score: 0.551 · Alzheimer's disease · 2026-04-21
## Mechanistic Overview Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscillations via astroc
Score: 0.546 · Alzheimer's disease · 2026-04-17
## Mechanistic Overview Closed-loop transcranial focused ultrasound with real-time gamma feedback to restore PV interneu
Score: 0.542 · Alzheimer's disease · 2026-04-21
## Mechanistic Overview Real-time closed-loop transcranial focused ultrasound targeting PV interneurons with API-integra
Score: 0.380 · unknown disease · 2026-04-27
This hypothesis combines closed-loop transcranial focused ultrasound (tFUS) with real-time API-guided adaptive targeting
Score: 0.353 · connectomics · 2026-04-25
Network-Directed Anti-Amyloid Immunotherapy via Transcranial Focused Ultrasound
Score: 0.000 · Alzheimer's disease · 2026-04-28
This intervention targets somatostatin-positive (SST) interneurons in the stratum oriens to restore hippocampal gamma os