🧫
miRNomic profiling and TGF-β content analysis in sEV
active
experiment
Created: 2026-04-06T12:31:46
By: etl-v1-backfill
Quality:
50%
✓ SciDEX
ID: exp-0da9af46-ae90-48ee-a6df-7be5e168248f
🧫 Experiment Protocol
Exploratorytype 2 diabetes mellitus, obesity, ischemic diseasemiR-130aserum-derived extracellular vesicles from human patientsproposed
This experiment involved comprehensive miRNA profiling and TGF-β protein content analysis in serum-derived extracellular vesicles from the different patient populations. The study specifically focused on identifying molecular markers that correlate with angiogenic properties. miRNA expression profiles were analyzed using miRNomic approaches, and TGF-β content was quantified. The results revealed that miR-130a and TGF-β content correlates with sEV in vitro and in vivo angiogenic properties, with particularly strong correlations observed in type 2 diabetic patients. This correlation analysis provided insights into the molecular mechanisms underlying the differential angiogenic capabilities of sEV from different patient populations.
PRIMARY OUTCOME
correlation between miR-130a/TGF-β content and angiogenic properties
EXPECTED OUTCOMES
Identification of molecular markers correlating with angiogenic capability
SUCCESS CRITERIA
Significant correlation between molecular markers and angiogenic properties
PROTOCOL
miRNomic profiling, TGF-β quantification, correlation analysis with angiogenic assay results
Source: PMID 31959759 ↗
🧫 Experiment Extras
PATHWAY
TGF-β signaling pathway, angiogenesis pathway
MARKET PRICE
$0.50
STATUS
proposed
▸Metadataorigin_type: v1_polymorphic_backfill
| origin_type | v1_polymorphic_backfill |
| source_table | experiments |
| _schema_version | 1 |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
0
Incoming
0
Outgoing
0
0 supporting
0 contradicting
0 neutral
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