cGAMP biomarker analysis in ALS patient spinal cord samples

Clinical Score: 0.850 Price: $0.50 amyotrophic lateral sclerosis human patients Status: proposed

What This Experiment Tests

Clinical experiment designed to assess clinical efficacy targeting N/A in human patients. Primary outcome: cGAMP levels in spinal cord tissue

Description

Analysis of spinal cord tissue samples from ALS" class="entity-link entity-disease" title="disease: ALS">ALS patients to measure levels of cyclic GMP-AMP (cGAMP), the specific metabolite produced by cGAS activation. This study aimed to validate the clinical relevance of cGAS/STING pathway activation in human ALS and establish cGAMP as a potential biomarker for mitochondrial DNA release and innate immune activation in ALS patients.

TARGET GENE

N/A

MODEL SYSTEM

human patients

ESTIMATED COST

TIMELINE

0 months

PATHWAY

cGAS/STING innate immune signaling

SOURCE

extracted_from_pmid_33031745

PRIMARY OUTCOME

cGAMP levels in spinal cord tissue

Scoring Dimensions

📖 Wiki Pages

STING Inhibitor Therapy in Neurodegenerationtherapeutic DNA Repair Therapy for Neurodegenerationtherapeutic DNA Damage Repair Therapy for Neurodegenerationtherapeutic ALS Treatment Strategiestherapeutic ALS Treatment Overviewtherapeutic ALS Therapeuticstherapeutic ALS Therapeutic Landscape — Programs by Phase and disease ALS Cure Roadmaptherapeutic ALS Communication Brain-Computer Interfacestechnology STING Proteinprotein STING Proteinredirect DNA-PKcs (PRKDC) Proteinprotein DNA Ligase IV Proteinprotein DNA Ligase III Proteinprotein STING-CASM-GABARAP-LRRK2 Pathway in Parkinson's Dimechanism

Protocol

Measurement of cGAMP metabolite levels in post-mortem spinal cord samples from ALS" class="entity-link entity-disease" title="disease: ALS">ALS patients compared to controls

Expected Outcomes

Elevated cGAMP levels in ALS" class="entity-link entity-disease" title="disease: ALS">ALS patient spinal cord samples

Success Criteria

Significantly higher cGAMP levels in ALS" class="entity-link entity-disease" title="disease: ALS">ALS patients versus controls

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