🧫
Brain tissue expression analysis of MDD risk genes
active
experiment
Created: 2026-04-06T12:30:40
By: etl-v1-backfill
Quality:
50%
✓ SciDEX
ID: exp-306925f6-be3c-4543-810c-fb9be647a88f
🧫 Experiment Protocol
Exploratorymajor depressive disorderFBXL4, RSRC1human brain tissueproposed
Expression quantitative trait loci (eQTL) analysis examining the relationship between identified risk variants and gene expression in human brain tissues. The study investigated whether genetic variants at the three novel risk loci (6q16.2, 12q24.31, and 16p13.3) were associated with differential expression of nearby genes. Additionally, mRNA expression analysis compared gene expression levels between MDD cases and controls in human brain tissue samples.
PRIMARY OUTCOME
differential gene expression in MDD vs controls
EXPECTED OUTCOMES
Risk variants associated with altered gene expression; differential expression of target genes in MDD
SUCCESS CRITERIA
significant association between variants and expression; significant differential expression in cases vs controls
PROTOCOL
eQTL analysis to correlate risk variants with gene expression levels. mRNA expression analysis comparing MDD cases versus control brain samples. Expression levels measured for genes in proximity to identified risk loci.
Source: PMID 29728651 ↗
🧫 Experiment Extras
PATHWAY
protein degradation, RNA processing
MARKET PRICE
$0.50
STATUS
proposed
▸Metadataorigin_type: v1_polymorphic_backfill
| origin_type | v1_polymorphic_backfill |
| source_table | experiments |
| _schema_version | 1 |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
0
Incoming
0
Outgoing
0
0 supporting
0 contradicting
0 neutral
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