Validation experiment designed to validate causal mechanisms targeting CD2AP in mice. Primary outcome: increased resting cerebral blood flow and protection against Aβ toxicity
Therapeutic intervention using reelin glycoprotein to mitigate CD2AP loss-of-function effects through ApoER2 receptor signaling. This experiment tested whether reelin treatment could rescue cerebrovascular dysfunction in CD2AP mutant mice by activating compensatory pathways. The study measured resting cerebral blood flow improvements and protection against amyloid-beta toxicity, with particular focus on male mice showing enhanced therapeutic response.
reelin glycoprotein treatment with cerebral blood flow measurement and Aβ challenge
restored cerebrovascular function and neuroprotection in male mice
improved blood flow and reduced Aβ-induced damage
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