🧫
LINC00599-MYH9 liquid-liquid phase separation analysis
active
experiment
Created: 2026-04-10T03:37:35
By: etl-v1-backfill
Quality:
50%
✓ SciDEX
ID: exp-48cd26c0-463c-4aa0-a054-959542070090
🧫 Experiment Protocol
ExploratoryPulmonary hypertensionLINC00599In vitro phase separation assaysproposed
This mechanistic study investigated the molecular interaction between LINC00599 and MYH9 (myosin heavy chain 9) through liquid-liquid phase separation. The research demonstrated that LINC00599 facilitates liquid-liquid phase separation with MYH9, which is a process previously implicated in cell-cycle regulation. This represents a novel mechanism by which long noncoding RNAs can regulate cellular processes, distinct from traditional RNA-protein interactions. The phase separation mechanism was shown to be critical for LINC00599's role in promoting PASMC proliferation and subsequent pulmonary hypertension progression.
PRIMARY OUTCOME
Liquid-liquid phase separation formation
EXPECTED OUTCOMES
LINC00599 facilitates phase separation with MYH9 to regulate cell proliferation
SUCCESS CRITERIA
Demonstration of phase separation complex formation between LINC00599 and MYH9
PROTOCOL
Analysis of LINC00599-MYH9 interaction through liquid-liquid phase separation assays
Source: PMID 40693377 ↗
🧫 Experiment Extras
PATHWAY
Liquid-liquid phase separation and cell cycle regulation
MARKET PRICE
$0.50
STATUS
proposed
▸Metadataorigin_type: v1_polymorphic_backfill
| origin_type | v1_polymorphic_backfill |
| source_table | experiments |
| _schema_version | 1 |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
0
Incoming
0
Outgoing
0
0 supporting
0 contradicting
0 neutral
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