Validation experiment designed to validate causal mechanisms targeting TBK1 in endothelium-specific TBK1 knockdown mice. Primary outcome: effect of TBK1 knockdown on EndMT and plaque formation
Endothelium-specific TBK1 knockdown mice were generated and used to investigate the role of TBK1 in endothelial-to-mesenchymal transition and atherogenesis. The study examined the effects of reducing TBK1 expression specifically in endothelial cells on atherosclerotic plaque formation and endothelial dysfunction. This genetic approach allowed for tissue-specific investigation of TBK1's role while avoiding systemic effects that might confound results.
endothelium-specific genetic knockdown of TBK1
reduced EndMT and atherosclerotic plaque formation
decreased endothelial dysfunction and plaque burden compared to controls
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