MAP6 depletion effects on neuronal development in primary cultures

Using the same primary rodent neuronal culture system, researchers examined the effects of MAP6 depletion on neuronal development parameters. This experiment served as a comparison to the tau depletion studies, testing the hypothesis that MAP6 and tau have antagonistic roles in regulating microtubule stability. The study measured the same developmental parameters as in the tau depletion experiment, including rate of neuronal development, growth cone turning efficiency, and formation of neuronal processes and axonal branches. The expectation was that MAP6 depletion would produce opposite effects to those observed with tau depletion.