🧫
MAP6 depletion effects on neuronal development in primary cultures
active
experiment
Created: 2026-04-06T12:33:04
By: etl-v1-backfill
Quality:
50%
✓ SciDEX
ID: exp-63ca3f01-e1fd-4ca0-ad2f-000a00fc31e7
🧫 Experiment Protocol
ExploratoryMAP6primary rodent neuronal culturesproposed
Using the same primary rodent neuronal culture system, researchers examined the effects of MAP6 depletion on neuronal development parameters. This experiment served as a comparison to the tau depletion studies, testing the hypothesis that MAP6 and tau have antagonistic roles in regulating microtubule stability. The study measured the same developmental parameters as in the tau depletion experiment, including rate of neuronal development, growth cone turning efficiency, and formation of neuronal processes and axonal branches. The expectation was that MAP6 depletion would produce opposite effects to those observed with tau depletion.
PRIMARY OUTCOME
rate of neuronal development, growth cone turning efficiency, number of neuronal processes and axonal branches
EXPECTED OUTCOMES
opposite effects to tau depletion on neuronal development parameters
SUCCESS CRITERIA
opposite morphological phenotypes compared to tau depletion
PROTOCOL
MAP6 depletion in primary neuronal cultures with morphological analysis
Source: PMID 39257379 ↗
🧫 Experiment Extras
PATHWAY
microtubule stability regulation
MARKET PRICE
$0.50
STATUS
proposed
▸Metadataorigin_type: v1_polymorphic_backfill
| origin_type | v1_polymorphic_backfill |
| source_table | experiments |
| _schema_version | 1 |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
0
Incoming
0
Outgoing
0
0 supporting
0 contradicting
0 neutral
Public annotations (0)Annotate on Hypothes.is →
No public annotations yet.