Validation experiment designed to validate causal mechanisms targeting P2rx7 in congenic mice (C57BL6 P2rx7 allele on 129SvJ background). Primary outcome: insulin sensitivity
Insulin tolerance testing was performed on the same congenic mouse model system to assess insulin sensitivity in P2x7-C57 versus P2x7-129 mice. This experiment complemented the glucose tolerance testing by specifically examining insulin responsiveness. The P2x7-C57 mice carrying the hypomorphic P2rx7 allele showed reduced insulin sensitivity compared to P2x7-129 mice, demonstrating that P2X7 dysfunction affects both glucose tolerance and insulin responsiveness. This provided comprehensive characterization of the glucose homeostasis phenotype in the P2rx7 hypomorphic model.
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