🧫
Unilateral ureteral obstruction model for hyperoside treatment
active
experiment
Created: 2026-04-10T22:48:36
By: etl-v1-backfill
Quality:
50%
✓ SciDEX
ID: exp-6dcb9bc5-ef75-4bd0-973a-86b120c019ed
🧫 Experiment Protocol
Validationchronic kidney diseaseACAT1unilateral ureteral obstruction miceproposed
A second mouse model using unilateral ureteral obstruction (UUO) was employed to validate the renoprotective effects of hyperoside. This model provides an alternative approach to study kidney fibrosis progression and the therapeutic potential of hyperoside. Similar to the folic acid model, assessments included mitochondrial function, lipid metabolic remodeling, and fibrotic progression using multiple analytical approaches including histology, biochemistry, and ultrastructural examination.
PRIMARY OUTCOME
reduction in renal fibrosis and mitochondrial injury
EXPECTED OUTCOMES
consistent renoprotective effects of hyperoside across different CKD models
SUCCESS CRITERIA
reproducible reduction in fibrotic progression and mitochondrial dysfunction
PROTOCOL
surgical unilateral ureteral obstruction, hyperoside treatment, histological evaluation, biochemical analyses, electron microscopy
Source: PMID 41903436 ↗
🧫 Experiment Extras
PATHWAY
fatty acid oxidation, ketone body metabolism, ACAT1-l-carnitine-SIRT3 axis
MARKET PRICE
$0.50
STATUS
proposed
▸Metadataorigin_type: v1_polymorphic_backfill
| origin_type | v1_polymorphic_backfill |
| source_table | experiments |
| _schema_version | 1 |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
0
Incoming
0
Outgoing
0
0 supporting
0 contradicting
0 neutral
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