🧫
DDT/DDE exposure and brain cortical thickness analysis
active
experiment
Created: 2026-04-12T17:54:56
By: etl-v1-backfill
Quality:
50%
✓ SciDEX
ID: exp-724a02f0-2d86-4b1b-a4a9-4c951bb53937
🧫 Experiment Protocol
Exploratoryneurodevelopmental effectshuman patientsproposed
A neuroimaging substudy examining associations between DDT and DDE exposure and brain structure using T1-weighted MRI in 95 women from the CHAMACOS cohort. The study measured cortical thickness across brain regions and evaluated associations with serum p,p'-DDT and p,p'-DDE concentrations measured 12 years earlier. Linear regression models were used to assess relationships between pesticide exposure and cortical thickness measurements, with particular focus on frontal lobe regions including medial orbitofrontal and pars orbitalis areas. The analysis controlled for potential confounders and co-exposures to other organochlorine pesticides.
PRIMARY OUTCOME
cortical thickness measurements
EXPECTED OUTCOMES
Pesticide exposure associated with altered brain structure
SUCCESS CRITERIA
Statistically significant associations between pesticide exposure and cortical thickness measures
PROTOCOL
T1-weighted brain MRI acquisition and processing for cortical thickness measurement. Linear regression analysis examining associations between historical serum pesticide concentrations and current brain structure measurements. Adjustment for covariates and organochlorine co-exposures.
Source: PMID 41965237 ↗
🧫 Experiment Extras
PATHWAY
organochlorine pesticide neurotoxicity
MARKET PRICE
$0.50
STATUS
proposed
▸Metadataorigin_type: v1_polymorphic_backfill
| origin_type | v1_polymorphic_backfill |
| source_table | experiments |
| _schema_version | 1 |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
0
Incoming
0
Outgoing
0
0 supporting
0 contradicting
0 neutral
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