🧫
S-equol anticancer efficacy in nude mouse xenograft TNBC model
active
experiment
Created: 2026-04-10T22:47:22
By: etl-v1-backfill
Quality:
50%
✓ SciDEX
ID: exp-7b408249-2294-4c7f-9720-f30df6c60822
🧫 Experiment Protocol
ValidationTriple negative breast cancerPPARγNude mouse xenograft tumor modelproposed
In vivo validation study using nude mouse xenograft tumor models to assess the anticancer effects of S-equol against triple negative breast cancer. TNBC cells were implanted into nude mice to establish xenograft tumors, followed by S-equol treatment to evaluate tumor growth suppression and therapeutic efficacy. The study aimed to validate the in vitro findings in a physiologically relevant animal model system and demonstrate the translational potential of S-equol as an anticancer agent. Results confirmed that S-equol treatment effectively suppressed TNBC tumor growth in vivo through ferroptosis induction.
PRIMARY OUTCOME
Tumor growth suppression
EXPECTED OUTCOMES
Reduced tumor growth and progression
SUCCESS CRITERIA
Significant inhibition of tumor growth compared to controls
PROTOCOL
Xenograft tumor establishment, S-equol treatment, tumor growth monitoring
Source: PMID 41925800 ↗
🧫 Experiment Extras
PATHWAY
PI3K/AKT/mTOR signaling pathway, ferroptosis pathway
MARKET PRICE
$0.50
STATUS
proposed
▸Metadataorigin_type: v1_polymorphic_backfill
| origin_type | v1_polymorphic_backfill |
| source_table | experiments |
| _schema_version | 1 |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
0
Incoming
0
Outgoing
0
0 supporting
0 contradicting
0 neutral
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