🧫
REV-ERB pharmacological activation blocks SD effects
active
experiment
Created: 2026-04-11T00:49:32
By: etl-v1-backfill
Quality:
50%
✓ SciDEX
ID: exp-8044c862-0843-458a-b6c7-8ad772490dc2
🧫 Experiment Protocol
ValidationdepressionNR1D1,NR1D2C57BL/6J miceproposed
This experiment tested whether pharmacological activation of the circadian clock repressor REV-ERB would suppress the antidepressant effects of sleep deprivation. The study demonstrated that REV-ERB agonist treatment blocked the rapid antidepressant behavioral effects normally produced by sleep deprivation, providing pharmacological evidence for the role of circadian clock mechanisms in mediating SD's therapeutic effects.
PRIMARY OUTCOME
Behavioral antidepressant response to sleep deprivation
EXPECTED OUTCOMES
Suppression of sleep deprivation's antidepressant effects by REV-ERB activation
SUCCESS CRITERIA
Significant reduction in antidepressant behavioral response compared to vehicle-treated controls
PROTOCOL
REV-ERB agonist administration followed by sleep deprivation and behavioral assessment
Source: PMID 41023421 ↗
🧫 Experiment Extras
PATHWAY
circadian rhythms,clock repression
MARKET PRICE
$0.50
STATUS
proposed
▸Metadataorigin_type: v1_polymorphic_backfill
| origin_type | v1_polymorphic_backfill |
| source_table | experiments |
| _schema_version | 1 |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
0
Incoming
0
Outgoing
0
0 supporting
0 contradicting
0 neutral
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