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Auditory nerve responses to combined optogenetic and electrical stimulation
active
experiment
Created: 2026-04-10T22:21:35
By: etl-v1-backfill
Quality:
50%
✓ SciDEX
ID: exp-83c46210-50b8-48d8-ba4c-d9cd8ddea4e2
🧫 Experiment Protocol
Validationsensorineural hearing loss/deafnessChR2-H134Rtransgenic mice expressing ChR2-H134R in auditory neuronsproposed
This study investigated the temporal precision of auditory nerve responses to three types of stimulation (optogenetic, electrical, and combined hybrid stimulation) in both acutely and chronically deafened transgenic mice. The researchers compared temporal fidelity (percentage of elicited responses) and precision (stability of response size and timing) using compound action potential and single-unit recordings from the auditory nerve. The study aimed to evaluate whether combined optogenetic-electrical stimulation could improve temporal precision while maintaining spatial precision, particularly examining how chronic deafness affects these responses compared to acute deafness models. The experiment used transgenic mice expressing ChR2-H134R opsin in auditory neurons and tested various combinations of sub-threshold and supra-threshold optogenetic power levels combined with electrical stimuli to optimize stimulation parameters for potential cochlear implant applications.
PRIMARY OUTCOME
temporal fidelity and precision of auditory nerve responses
EXPECTED OUTCOMES
Combined stimulation would improve temporal precision without sacrificing spatial precision by facilitating electrical activation thresholds
SUCCESS CRITERIA
Improved temporal fidelity (percentage of elicited responses) and precision (stability of response size and timing) with hybrid stimulation
PROTOCOL
Compound action potential and single-unit recordings of auditory nerve responses to electrical, optogenetic, and hybrid stimulation in acutely and chronically deafened mice
LINKED HYPOTHESES
Source: PMID 36963106 ↗
🧫 Experiment Extras
PATHWAY
optogenetic neural activation pathway
MARKET PRICE
$0.50
STATUS
proposed
▸Metadataorigin_type: v1_polymorphic_backfill
| origin_type | v1_polymorphic_backfill |
| source_table | experiments |
| _schema_version | 1 |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
0
Incoming
0
Outgoing
0
0 supporting
0 contradicting
0 neutral
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