🧫
Plant-based dietary patterns and Alzheimer's disease risk in multiethnic cohort
active
experiment
Created: 2026-04-10T22:37:16
By: etl-v1-backfill
Quality:
50%
✓ SciDEX
ID: exp-87c2923f-801b-4134-b98a-f7059a02ae7c
🧫 Experiment Protocol
ClinicalAlzheimer's disease and related dementiashuman patientsproposed
This prospective longitudinal cohort study examined the association between plant-based dietary patterns and their changes over time with incident Alzheimer's disease and related dementias (ADRDs) in a large multiethnic population. The study utilized the Multiethnic Cohort Study based in Hawaii and California, following participants from baseline (1993-1996) through 10-year follow-up (2003-2008) with linked Medicare claims data to identify incident ADRD cases. Three plant-based diet indices were analyzed: overall plant-based diet index (PDI), healthful plant-based diet index (hPDI), and unhealthful plant-based diet index (uPDI). The study examined both baseline dietary patterns and changes in dietary patterns over the 10-year period. Participants included African American, Japanese American, Latino, Native Hawaiian, and White individuals aged 45-75 years at baseline. Food frequency questionnaires were used to assess dietary intake at both time points. Cox regression models were employed to examine associations between dietary indices and ADRD risk, adjusting for relevant covariates.
PRIMARY OUTCOME
Incident Alzheimer's disease and related dementias identified through Medicare claims
EXPECTED OUTCOMES
Higher quality plant-based diets (higher PDI and hPDI) were expected to be associated with lower ADRD risk, while unhealthful plant-based diets (higher uPDI) were expected to increase risk
SUCCESS CRITERIA
- Prespecified primary endpoint (Incident Alzheimer's disease and related dementias identified through Medicare claims) improves versus control with p < 0.05 or an equivalent corrected threshold used by the study.
- The effect size is biologically meaningful and reproduced across technical/biological replicates or the validation subset.
- Safety, data quality, and missingness remain within protocol-defined bounds so the result is interpretable rather than driven by attrition or assay failure.
PROTOCOL
Prospective longitudinal cohort study using food frequency questionnaires at baseline (1993-1996) and 10-year follow-up (2003-2008), with Medicare claims linkage for ADRD identification. Three a priori plant-based diet indices (PDI, hPDI, uPDI) were calculated and analyzed using Cox regression models.
LINKED HYPOTHESES
h-var-b7e4505525· Closed-loop transcranial focused ultrasound targeting EC-II SST interneurons to restore hippocampal gamma oscillations vh-var-f110ef2e0a· Closed-loop transcranial focused ultrasound targeting EC-II SST interneurons to prevent tau propagation and restore entoh-var-a4975bdd96· Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscillations via cholecystokinin interneuron ne
Source: PMID 41950435 ↗
🧫 Experiment Extras
MARKET PRICE
$0.50
STATUS
proposed
Prediction Markets (3 direct, 0 via hypothesis — 3 total)
Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscillations via YES 78% · Liq $100 · resolvedClosed-loop transcranial focused ultrasound targeting EC-II SST interneurons to prevent taYES 71% · Liq $100 · activeClosed-loop transcranial focused ultrasound targeting EC-II SST interneurons to restore hiYES 78% · Liq $100 · resolved▸Metadataorigin_type: v1_polymorphic_backfill
| origin_type | v1_polymorphic_backfill |
| source_table | experiments |
| _schema_version | 1 |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
0
Incoming
0
Outgoing
0
0 supporting
0 contradicting
0 neutral
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