Clinical experiment designed to assess clinical efficacy targeting N/A in human patients. Primary outcome: Incident Alzheimer's disease and related dementias identified through Medicare claims
This prospective longitudinal cohort study examined the association between plant-based dietary patterns and their changes over time with incident Alzheimer's disease and related dementias (ADRDs) in a large multiethnic population. The study utilized the Multiethnic Cohort Study based in Hawaii and California, following participants from baseline (1993-1996) through 10-year follow-up (2003-2008) with linked Medicare claims data to identify incident ADRD cases. Three plant-based diet indices were analyzed: overall plant-based diet index (PDI), healthful plant-based diet index (hPDI), and unhealthful plant-based diet index (uPDI). The study examined both baseline dietary patterns and changes in dietary patterns over the 10-year period. Participants included African American, Japanese American, Latino, Native Hawaiian, and White individuals aged 45-75 years at baseline. Food frequency questionnaires were used to assess dietary intake at both time points. Cox regression models were employed to examine associations between dietary indices and ADRD risk, adjusting for relevant covariates.
Prospective longitudinal cohort study using food frequency questionnaires at baseline (1993-1996) and 10-year follow-up (2003-2008), with Medicare claims linkage for ADRD identification. Three a priori plant-based diet indices (PDI, hPDI, uPDI) were calculated and analyzed using Cox regression models.
Statistically significant associations between dietary indices and ADRD risk in Cox regression models
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