🧫
Bidirectional Mendelian randomization analysis of C1Q and ischemic stroke
active
experiment
Created: 2026-04-06T12:27:52
By: etl-v1-backfill
Quality:
50%
✓ SciDEX
ID: exp-8bbb2e1e-9c23-4d2b-9e8f-0bdc192c9813
🧫 Experiment Protocol
ExploratoryIschemic stroke, AtherosclerosisC1QHuman genetic association dataproposed
This genetic epidemiological study employed bidirectional Mendelian randomization (MR) analysis to investigate the causal relationship between C1Q levels and ischemic stroke risk, specifically focusing on large artery atherosclerosis subtype. The analysis used genetic variants associated with C1Q as instrumental variables to assess causality while avoiding confounding factors that typically plague observational studies. Inverse variance weighting (IVW) was employed as the primary statistical method. The bidirectional approach allowed assessment of causality in both directions - whether C1Q influences stroke risk and whether stroke risk influences C1Q levels. This approach leverages the random assortment of genetic variants to provide evidence for causal relationships.
PRIMARY OUTCOME
Causal association between C1Q and ischemic stroke risk
EXPECTED OUTCOMES
Identification of causal relationship between C1Q and stroke risk
SUCCESS CRITERIA
Statistically significant association with appropriate confidence intervals
PROTOCOL
Bidirectional Mendelian randomization analysis using IVW as primary method, with C1Q as exposure and ischemic stroke as outcome
LINKED HYPOTHESES
Source: PMID 38179058 ↗
🧫 Experiment Extras
PATHWAY
Complement signaling pathway
MARKET PRICE
$0.50
STATUS
proposed
▸Metadataorigin_type: v1_polymorphic_backfill
| origin_type | v1_polymorphic_backfill |
| source_table | experiments |
| _schema_version | 1 |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
0
Incoming
0
Outgoing
0
0 supporting
0 contradicting
0 neutral
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