🧫
CSF iron content analysis in RLS patients versus controls
active
experiment
Created: 2026-04-10T22:36:47
By: etl-v1-backfill
Quality:
50%
✓ SciDEX
ID: exp-910d2896-9d63-4791-a2ef-2379d1e9b673
🧫 Experiment Protocol
Clinicalrestless legs syndromehuman patientsproposed
This clinical study analyzed cerebrospinal fluid (CSF) samples from restless legs syndrome (RLS) patients and healthy controls to measure iron content. The researchers measured both free iron and protein-bound iron concentrations in CSF samples. This analysis was conducted to characterize the iron status in the central nervous system of RLS patients compared to controls, providing evidence for the brain iron deficiency that is considered a pathophysiological hallmark of RLS. The results showed that both free and protein-bound iron levels were decreased in CSF from RLS subjects compared to controls, supporting the hypothesis of brain iron deficiency in RLS and providing the rationale for the subsequent cell-based experiments using this CSF.
PRIMARY OUTCOME
CSF iron content (free and protein-bound)
EXPECTED OUTCOMES
Decreased iron levels in RLS CSF compared to controls
SUCCESS CRITERIA
Significant difference in CSF iron content between groups
PROTOCOL
CSF samples collected from RLS patients (n=14) and controls (n=15), analyzed for free and protein-bound iron concentrations
Source: PMID 41947413 ↗
🧫 Experiment Extras
PATHWAY
iron homeostasis
MARKET PRICE
$0.50
STATUS
proposed
▸Metadataorigin_type: v1_polymorphic_backfill
| origin_type | v1_polymorphic_backfill |
| source_table | experiments |
| _schema_version | 1 |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
0
Incoming
0
Outgoing
0
0 supporting
0 contradicting
0 neutral
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