Validation experiment designed to validate causal mechanisms targeting CD2AP in mice. Primary outcome: memory function impairment
Genetic downregulation of CD2AP specifically in brain vascular endothelial cells to assess the impact on memory function in mice. This experiment examined whether loss of endothelial CD2AP causes cognitive impairments, with particular focus on sex-dependent effects. Male mice showed impaired memory function when brain endothelial CD2AP was reduced.
genetic downregulation of CD2AP in brain vascular endothelial cells, behavioral testing
memory impairment in mice with reduced endothelial CD2AP
significant difference in memory performance between control and CD2AP-deficient mice
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