Exploratory experiment designed to discover new patterns targeting Multiple EMT-related genes in Primary mouse model. Primary outcome: EMT state classification and gene expression profiles
This experiment used single-cell RNA sequencing to characterize different EMT states in control and NP137-treated squamous cell carcinomas. The analysis revealed the presence of distinct EMT states including epithelial, early hybrid EMT, late hybrid EMT, and full EMT states in control SCC samples. The study demonstrated that NP137 administration prevented cancer cell progression toward late EMT states and helped maintain tumor epithelial states. This comprehensive transcriptomic analysis provided molecular insights into how netrin-1 inhibition affects EMT progression at the single-cell level.
Single-cell RNA sequencing of tumor samples from control and NP137-treated mice, followed by computational analysis of EMT states
Prevention of late EMT state progression and maintenance of epithelial states with NP137 treatment
Clear identification of EMT states and demonstration of NP137 effects on EMT progression
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