🧫
Stress-induced depression model sleep architecture analysis
active
experiment
Created: 2026-04-11T00:49:32
By: etl-v1-backfill
Quality:
50%
✓ SciDEX
ID: exp-aefcff57-e779-4dc1-bf43-15a119e806a9
🧫 Experiment Protocol
ValidationdepressionHOMER1A,GRIA1,GRIA2,GRIA3,GRIA4C57BL/6J mice with stress-induced depressionproposed
This experiment examined sleep regulation and homeostatic glutamatergic plasticity in the medial prefrontal cortex (mPFC) of mice with stress-induced depression-like phenotype. The study characterized altered sleep architecture, impaired sleep homeostasis, and disrupted day-night oscillations of glutamatergic plasticity markers including Homer1a and synaptic AMPAR expression. The mice showed blunted response to sleep deprivation with impaired rebound slow-wave activity, attenuated recovery sleep, and altered upregulation of Homer1a and AMPAR compared to controls.
PRIMARY OUTCOME
Sleep architecture parameters and glutamatergic plasticity markers
EXPECTED OUTCOMES
Altered sleep patterns and disrupted circadian oscillations of plasticity markers in depression model
SUCCESS CRITERIA
Significant changes in sleep parameters and molecular markers compared to control mice
PROTOCOL
Sleep monitoring, behavioral assessments, molecular analysis of mPFC tissue for Homer1a and AMPAR expression across day-night cycles
Source: PMID 41023421 ↗
🧫 Experiment Extras
PATHWAY
glutamatergic signaling,synaptic plasticity,circadian rhythms
MARKET PRICE
$0.50
STATUS
proposed
▸Metadataorigin_type: v1_polymorphic_backfill
| origin_type | v1_polymorphic_backfill |
| source_table | experiments |
| _schema_version | 1 |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
0
Incoming
0
Outgoing
0
0 supporting
0 contradicting
0 neutral
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