🧫
bEV isolation and LPS quantification from human samples
active
experiment
Created: 2026-04-10T22:33:25
By: etl-v1-backfill
Quality:
50%
✓ SciDEX
ID: exp-b0fe6027-ebcb-45e8-8f91-44a99e98f488
🧫 Experiment Protocol
ClinicalAlzheimer's diseasehuman patientsproposed
This experiment involved the extraction of bacterial extracellular vesicles (bEVs) from fecal and blood samples of Alzheimer's disease patients and healthy controls. The researchers measured LPS levels within these bEVs to determine if AD patients showed elevated LPS-containing bEVs compared to healthy individuals. The study aimed to establish a clinical correlation between gut microbiota-derived vesicles and AD pathology by demonstrating increased LPS-carrying bEVs in patient plasma.
PRIMARY OUTCOME
LPS levels in bacterial extracellular vesicles
EXPECTED OUTCOMES
Elevated LPS-containing bEVs in AD patients compared to healthy controls
SUCCESS CRITERIA
Statistically significant difference in LPS-containing bEVs between AD patients and controls
PROTOCOL
Extraction of bEVs from human feces and blood samples, followed by LPS level measurement
LINKED HYPOTHESES
h-var-70a95f9d57· LPCAT3-Mediated Lands Cycle Amplification of Ferroptotic Vulnerability in Disease-Associated Microgliah-var-c56b26facf· LPCAT3-Mediated Lands Cycle Amplification of Ferroptotic Substrate Pools in Disease-Associated Microgliah-4dd0d19b· LRP1-Dependent Tau Uptake Disruptionh-b234254c· TREM2-mediated microglial tau clearance enhancementh-55ef81c5· Extracellular Vesicle Biogenesis Modulation
Source: PMID 40731189 ↗
🧫 Experiment Extras
PATHWAY
gut-brain axis communication
MARKET PRICE
$0.50
STATUS
proposed
Prediction Markets (1 direct, 0 via hypothesis — 1 total)
bEV isolation and LPS quantification from human samples — will this experiment confirm theYES 95% · Liq $100 · active▸Metadataorigin_type: v1_polymorphic_backfill
| origin_type | v1_polymorphic_backfill |
| source_table | experiments |
| _schema_version | 1 |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
0
Incoming
0
Outgoing
0
0 supporting
0 contradicting
0 neutral
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