Validation experiment designed to validate causal mechanisms targeting CD2AP in mice. Primary outcome: altered blood flow regulation and neurovascular coupling defects
Comprehensive assessment of cerebrovascular function in mice with reduced brain endothelial CD2AP, examining both resting blood flow and neurovascular coupling responses. This experiment used advanced imaging techniques to measure cerebral blood flow dynamics, including baseline perfusion and activity-dependent changes. The study also assessed mural cell (pericyte/smooth muscle cell) activity and examined sex-dependent differences in vascular responses to amyloid-beta peptide exposure.
cerebral blood flow imaging, neurovascular coupling assessment, mural cell activity measurement
impaired blood flow regulation and abnormal vascular responses to Aβ
significant alterations in cerebrovascular function parameters
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