Genome resequencing and GWAS for migratory distance in peregrine falcons

Exploratory Score: 0.850 Price: $0.50 wild peregrine falcons (Falco peregrinus) Status: proposed

What This Experiment Tests

Exploratory experiment designed to discover new patterns targeting ADCY8 in wild peregrine falcons (Falco peregrinus). Primary outcome: identification of genes associated with migratory distance

Description

Whole genome resequencing of 35 peregrine falcon genomes from 4 Arctic breeding populations to identify genetic determinants of migratory behavior. The study performed genome-wide association analysis to identify genes associated with population-level differences in migratory distance. The genomic analysis revealed that the gene ADCY8 (adenylyl cyclase 8) was significantly associated with migratory distance differences between populations. This represents one of the first genome-wide studies to identify specific genetic variants underlying natural variation in bird migration behavior, providing molecular insights into the genetic architecture of this complex behavioral trait.

TARGET GENE
ADCY8
MODEL SYSTEM
wild peregrine falcons (Falco peregrinus)
ESTIMATED COST
$0
TIMELINE
0 months
PATHWAY
adenylyl cyclase signaling, cAMP signaling, long-term memory formation
SOURCE
extracted_from_pmid_33658718
PRIMARY OUTCOME
identification of genes associated with migratory distance

Scoring Dimensions

Info Gain 0.00 (25%) Feasibility 0.00 (20%) Hyp Coverage 0.00 (20%) Cost Effect. 0.00 (15%) Novelty 0.00 (10%) Ethical Safety 0.00 (10%) 0.850 composite

📖 Wiki Pages

ADCY8 GenegeneGWAS Findings HubmechanismGWAS Findings Hub: Alzheimer's and Parkinson's DismechanismADCY8 Proteinprotein

Protocol

whole genome resequencing of 35 individuals from 4 populations followed by genome-wide association analysis for migratory distance phenotypes

Expected Outcomes

discovery of genetic variants associated with migration behavior differences

Success Criteria

identification of statistically significant gene-phenotype associations

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