🧫
Folic acid-induced nephropathy model for hyperoside renoprotection
active
experiment
Created: 2026-04-10T22:48:36
By: etl-v1-backfill
Quality:
50%
✓ SciDEX
ID: exp-c50aa3c4-be1f-4623-bc37-6c081e03e9f7
🧫 Experiment Protocol
Validationchronic kidney diseaseACAT1folic acid-induced nephropathy miceproposed
Mouse model of chronic kidney disease was established using folic acid administration to induce nephropathy. Mice were treated with hyperoside to evaluate its renoprotective effects against kidney fibrosis. The study assessed mitochondrial function, lipid metabolism, and fibrotic progression through histological evaluation, biochemical analyses, and electron microscopy. Multi-omics approaches including transcriptomics and metabolomics were employed to characterize metabolic pathway modulation by hyperoside treatment.
PRIMARY OUTCOME
reduction in renal fibrosis and mitochondrial injury
EXPECTED OUTCOMES
hyperoside would reduce renal fibrosis and improve mitochondrial function
SUCCESS CRITERIA
significant reduction in fibrotic markers and improved mitochondrial morphology and function
PROTOCOL
folic acid administration to induce nephropathy, hyperoside treatment, histological evaluation, biochemical analyses, electron microscopy, transcriptomic and metabolomic analyses
Source: PMID 41903436 ↗
🧫 Experiment Extras
PATHWAY
fatty acid oxidation, ketone body metabolism, ACAT1-l-carnitine-SIRT3 axis
MARKET PRICE
$0.50
STATUS
proposed
▸Metadataorigin_type: v1_polymorphic_backfill
| origin_type | v1_polymorphic_backfill |
| source_table | experiments |
| _schema_version | 1 |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
0
Incoming
0
Outgoing
0
0 supporting
0 contradicting
0 neutral
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