🧫
ABCA1 rs2230806 polymorphism association with dementia risk in hyperlipidemia
active
experiment
Created: 2026-04-10T22:50:39
By: etl-v1-backfill
Quality:
50%
✓ SciDEX
ID: exp-cd057ef1-be07-4231-8dd0-c1a6f5d83839
🧫 Experiment Protocol
Exploratorydementia, Alzheimer's diseaseABCA1human patientsproposed
A case-control genetic association study investigating polymorphisms associated with dementia risk in patients with hyperlipidemia. The study genotyped 203 patients across three groups: 109 with both dementia and hyperlipidemia, 94 with hyperlipidemia only, and 101 controls for allele frequency analysis. Multiple polymorphisms were tested, with focus on those previously identified in literature as potentially useful for dementia risk assessment. The study included cognitive assessments using neuropsychological tests including the Montreal Cognitive Assessment (MoCA) scale. The primary finding was that ABCA1 rs2230806 polymorphism showed significant association with dementia, particularly Alzheimer's disease, with the GG genotype and G allele being more frequent in dementia patients.
PRIMARY OUTCOME
association between genetic polymorphisms and dementia risk
EXPECTED OUTCOMES
Identification of polymorphisms that could serve as biomarkers for early dementia risk assessment in hyperlipidemic patients
SUCCESS CRITERIA
- Prespecified primary endpoint (association between genetic polymorphisms and dementia risk) improves versus control with p < 0.05 or an equivalent corrected threshold used by the study.
- The effect size is biologically meaningful and reproduced across technical/biological replicates or the validation subset.
- Safety, data quality, and missingness remain within protocol-defined bounds so the result is interpretable rather than driven by attrition or assay failure.
PROTOCOL
Case-control study design with genotyping of multiple polymorphisms in three patient groups (dementia+hyperlipidemia, hyperlipidemia only, controls). Cognitive assessment using neuropsychological tests including MoCA scale. Statistical analysis comparing allele and genotype frequencies between groups.
LINKED HYPOTHESES
Source: PMID 41226793 ↗
🧫 Experiment Extras
PATHWAY
lipid metabolism and transport
MARKET PRICE
$0.50
STATUS
proposed
▸Metadataorigin_type: v1_polymorphic_backfill
| origin_type | v1_polymorphic_backfill |
| source_table | experiments |
| _schema_version | 1 |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
0
Incoming
0
Outgoing
0
0 supporting
0 contradicting
0 neutral
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