🧫
HOXA5 gain-of-function validation as miR-130a target
active
experiment
Created: 2026-04-06T12:31:46
By: etl-v1-backfill
Quality:
50%
✓ SciDEX
ID: exp-cd0c6ec0-ca30-467a-b2a7-61d004b75c79
🧫 Experiment Protocol
Exploratorytype 2 diabetes mellitus, obesity, ischemic diseaseHOXA5, miR-130acell culture systems for gain-of-function studiesproposed
This experiment involved gain-of-function studies to validate homeoboxA5 (HOXA5) as a specific target of miR-130a. The study aimed to demonstrate the functional relationship between miR-130a and HOXA5 in the context of angiogenic regulation. Gain-of-function experiments were performed, likely involving overexpression or restoration of HOXA5 function to assess its role in angiogenesis and its regulation by miR-130a. This functional validation experiment provided direct evidence that HOXA5 is a biologically relevant target of miR-130a in the context of extracellular vesicle-mediated angiogenic signaling.
PRIMARY OUTCOME
validation of HOXA5 as miR-130a target
EXPECTED OUTCOMES
demonstration of functional miR-130a-HOXA5 regulatory relationship
SUCCESS CRITERIA
measurable effects of HOXA5 manipulation on angiogenic properties
PROTOCOL
gain-of-function experiments with HOXA5 overexpression or functional restoration
Source: PMID 31959759 ↗
🧫 Experiment Extras
PATHWAY
angiogenesis pathway, HOX gene regulatory networks
MARKET PRICE
$0.50
STATUS
proposed
▸Metadataorigin_type: v1_polymorphic_backfill
| origin_type | v1_polymorphic_backfill |
| source_table | experiments |
| _schema_version | 1 |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
0
Incoming
0
Outgoing
0
0 supporting
0 contradicting
0 neutral
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