Preinjury ACE-I/ARB exposure and outcomes in transfused trauma patients

This retrospective clinical study evaluated the association between preinjury angiotensin-converting enzyme inhibitor (ACE-I) or angiotensin II receptor blocker (ARB) medication use and clinical outcomes in trauma patients who received blood product transfusions during resuscitation. The study compared patients who had been taking ACE-I/ARB medications prior to their injury with those who had not been taking these medications. The researchers examined demographics, complication rates, blood product transfusion volumes, and mortality outcomes. The study aimed to determine if preinjury use of renin-angiotensin-aldosterone system modulators affected patient outcomes following traumatic injury requiring blood transfusion. Both univariate and multivariable analyses were performed to identify independent predictors of mortality, with adjustment for potential confounding variables including age, mechanism of injury, vital signs, laboratory values, and injury severity.